Cyclophosphamide is a potent cytotoxic agent used in many clinical settings. The main risks of cyclophosphamide therapy include hematological disorders, infertility, hemorrhagic cystitis and malignancies. Gastrointestinal side effects reported to date are often non-specific and not severe. We present the first case of a fatal small bowel enteritis and pan-colitis which appears to be associated ...

PURPOSE OF REVIEW Induction treatment of antineutrophil cytoplasmic antibodies (ANCA) associated vasculitis (AAV) is not always successful and nonresponding patients are considered refractory. RECENT FINDINGS Refractory disease should be subdefined to the treatment that was received. Cyclophosphamide refractory AAV occurs in up to 5% of patients. Many more patients develop contraindications t...

Cyclophosphamide has long been known to be an extremely effective immunosuppressant in rodents. In humans, the drug has been used extensively for cancer chemotherapy and for the treatment of autoimmune disorders. Several years ago cyclophosphamide was introduced by Santos and his associates into to the field of clinical bone marrow grafting. There are probably tho reasons why cyclophosphamide h...

BEGINNING 15 mo ago, at the University of Colorado, the alkylating agent, cyclophosphamide (Cytoxan), has been given an extensive clinical trial in the treatment of whole organ recipients both early and late after transplantation. This communication will deal only with those cases of renal homotransplantation in which cyclophosphamide was used from the outset. The late substitution of cyclophos...

BACKGROUND Corticosteroids are the systemic treatment of choice in patients with pemphigus vulgaris, but chronic administration is associated with side effects. Intravenous treatment with cyclophosphamide can improve the clinical signs of pemphigus vulgaris. MATERIAL AND METHODS We prospectively studied 8 patients diagnosed with pemphigus vulgaris. Six of these had mucocutaneous pemphigus vul...

A cyclophosphamide-resistant L1210 cell line has been shown to have unusually high aldehyde dehydrogenase activity. The sensitivity of this cell line to 4-methylcyclophosphamide and phosphoramide mustard in vivo and corresponding sensitivities in vitro indicate that 4-hydroxycyclophosphamide and/or aldophosphamide is the form in which cyclophosphamide reaches these tumor cells in mice and that ...