Objectives: Graft versus host disease (GVHD) is a life threatening reaction in the stem cell transplantation process. Nowadays Cyclosporine is the most commonly utilized agent for GVHD prophylaxis and it has a major role in successful transplantation. Cyclosporine has been applied for many years in this field but it could be stated that currently no general consensus is available for its optima...

To identify the mechanism of cyclosporine-induced hypertension, we studied the effect of cyclosporine on the catecholamine synthetic pathway in rats. We administered cyclosporine (10 mg/kg per day, s.c.) for 3 days to 10-week-old male Wistar rats. Systolic blood pressure increased significantly in the cyclosporine-treated group in comparison to that in the control group. Norepinephrine and epin...

this study was designed to investigate the effects of tangerine, orange, and grapefruit juice on the pharmacokinetic pattern of cyclosporine a in rats. forty male sprague-dawley rats were divided into four groups to receive water, orange, tangerine, or grapefruit juices respectively. water or juices (10 ml/kg) were given orally twice a day for 3 days. three hours after the 5 th dose, cyclospori...

OBJECTIVES The long-term use of cyclosporine always contributes to chronic renal allograft dysfunction. Converting from cyclosporine to sirolimus and reducing cyclosporine dosage under high mycophenolate mofetil levels are 2 common therapies. Their efficacy and safety have not been compared in Chinese patients. MATERIALS AND METHODS In this prospective, open label, randomized study, 51 kidney...

BACKGROUND We previously established a treatment protocol for conventional cyclosporine (Sandimmune, Novartis, Basel, Switzerland) in children with frequently relapsing nephrotic syndrome; ∼50% of patients remained relapse free for 2 years, without serious adverse events. Recently, microemulsified cyclosporine (Neoral, Novartis), which has a more stable absorption profile than conventional cycl...

The question of whether pharmacological inhibition of the thromboxane A2 activity prevents cyclosporine-induced chronic renal dysfunction in a Lewis rat model of renal isograft was addressed. Transplanted animals were given a daily oral dose of cyclosporine (20 mg/kg; N = 15), cyclosporine (20 mg/kg) and the thromboxane A2 receptor antagonist GR32191 (3 mg/kg twice daily, by gavage; N = 15), or...

background: the current immunosuppressive treatment of patients with autoimmune hepatitis (aih) consists of prednisolone and azathioprine. high doses of prednisolone used for disease remission are not universally effective and have serious adverse effects. some authors have provided evidence of aih therapy in children and adults with cyclosporine (neoral) should corticosteroid therapy become in...

background and objective: artimisinin (an anti-malaria drug) is extracted from artemisia annua and its water soluble derivative is dihydroartimisinin. previous in vivo and in vitro studies showed that it has an inhibitory effect on t cells. it is also useful for immunosuppression of immune system. materials and methods: the stable state kinetic for comparison of inhibitory effect of artimisinin...