Background: Prolonged use of cyclosporine A for prevention of allograft rejection is associated with nephrotoxicity development. Naringenin and olive oil are beneficial dietary antioxidants with potential renoprotective properties. This study aimed to evaluate the therapeutic effect of naringenin and olive oil in alleviating cyclosporine induced nephrotoxicity in rats by the assessment of renal...

background and objective: artimisinin (an anti-malaria drug) is extracted from artemisia annua and its water soluble derivative is dihydroartimisinin. previous in vivo and in vitro studies showed that it has an inhibitory effect on t cells. it is also useful for immunosuppression of immune system. materials and methods: the stable state kinetic for comparison of inhibitory effect of artimisinin...

purpose: to determine whether adding 2% topical cyclosporine (csa) to local and systemic steroids in treatment of endothelial corneal allograft rejection improves the outcome. methods: a prospective randomized treatment trial was carried out on 40 consecutive corneal graft recipients, presenting with the first episode of endothelial graft rejection in two groups. group one (20 patients) receive...

Background: Infertility is a disease of the reproductive system that inhibits the ability of a couple to have a Baby. Cyclosporine A (CsA) is a powerful immunosuppressant drug most widely used in management of organ transplantation and autoimmune diseases. The drug has adverse side effects such, hirsutism, and gynecomastia. Hawthorn is one of the oldest herbal medicines that are widely used in ...

background: prolonged use of cyclosporine a for prevention of allograft rejection is associated with nephrotoxicity development. naringenin and olive oil are beneficial dietary antioxidants with potential renoprotective properties. this study aimed to evaluate the therapeutic effect of naringenin and olive oil in alleviating cyclosporine induced nephrotoxicity in rats by the assessment of renal...

spermatogenesis process during which the male germ cells are produced at each stage of the disorder, it can lead to infertility. the aim of this study was to evaluate the effect of fennel and yarrow on spermatogenesis in adult micereceiving chemotherapy is cyclosporine. for this study, 32 male wistar rats with an average weight of 20 ± 200 g were randomly divided into four groups (control, cycl...

This study was designed to investigate the effects of tangerine, orange, and grapefruit juice on the pharmacokinetic pattern of cyclosporine A in rats. Forty male Sprague-Dawley rats were divided into four groups to receive water, orange, tangerine, or grapefruit juices respectively. Water or juices (10 ml/kg) were given orally twice a day for 3 days. Three hours after the 5th dose, cyclosporin...

Laser Raman spectroscopy has been employed to investigate the effects of cyclosporine-A on the order and dynamics of DPPC (Dipalmytoyl Phosphatidyl Choline) midel membrane system. It is shown that the addition of small amount of cyclosporine-A to a DPPC dispersion disturb the system and changes the order/disorder parameter of the model membrane.

this study was designed to investigate the effects of tangerine, orange, and grapefruit juice on the pharmacokinetic pattern of cyclosporine a in rats. forty male sprague-dawley rats were divided into four groups to receive water, orange, tangerine, or grapefruit juices respectively. water or juices (10 ml/kg) were given orally twice a day for 3 days. three hours after the 5 th dose, cyclospori...