Th1 lymphocytes produce cytokines such as IL-2, IFN-γ, and TNF-α, TNF-β and GM-CSF and play an important role in the increase of delaying sensitivity and defense against intracellular pathogens. IFN-γ is the most important Th1 cell cytokine that induces the production of IgG, activation of macrophages,enhancing phagocytosis, and also increasing MHC class I and class II mo...

neovascularization of the normally avascular cornea was associated with a notable increase in the expression of the major pro-angiogenic factors, inflammatory cytokines and proteases. the data supporting a causal role for vascular endothelial growth factor (vegf), inflammatory cytokines and matrix metalloproteinase (mmps) are extensive. anti-angiogenic/anti-inflammatory therapy is considered as...

background: cesarean section delivery can lead to much maternal morbidity. different cytokines have been reported to be influenced by the mode of delivery. objective: to investigate the influence of mode of delivery on maternal, placental and cord sera of interferon gamma (ifn-γ), interleukin-4 (il-4) and interleukin-10 (il-10) levels. methods: these three cytokines were measured using elisa in...

the early cytokines production in response to live logarithmic and stationary phase promastigotes of leishmania major was examined on the peripheral blood cells of the healthy individuals. whole blood cultures were stimulated by either logarithmic or stationary phase promastigotes. ifn- and il-10 productions were assessed by specific sandwich elisa. the results showed that the logarithmic prom...

conclusions the changes of treg and th17 cells and their associated cytokines were related to virological and biochemical responses. results in complete and partial-responders, treg cells frequencies and il-10, tgf-β1, il-23 levels were all decreased significantly after na therapy, while th17 cells and the il-17 levels were increased slightly. treg/th17 ratio was only dramatically declined in c...

estrogen (e2) has neuroprotective effects on blood-brain-barrier (bbb) after traumatic brain injury (tbi). in order to investigate the roles of estrogen receptors (ers) in these kind of effects, er-α antagonist (mpp) and, er-β antagonist (phtpp), or non-selective estrogen receptors antagonist (ici 182780) were administered as regulators of cns cytokines levels and neuroinflammation after tbi. m...

introduction:to evaluate the role of allergic-type and infectious-type cytokines in children with chronic otitis media with effusion (ome) materials and methods:we investigated serum levels of interleukins (il)-4, il-5, and il-13, along with interferon-gamma (ifn-γ) and tumor necrosis factor-alpha (tnf-α), by enzyme-linked immunosorbent assay (elisa) in 35 children with ome and 28 healthy contr...