Objective(s): Tuberculosis (TB) has still remained a global health issue. One third of the world's population is infected with tuberculosis and the current BCG vaccine has low efficiency; hence, it is necessary to develop a new vaccine against TB. The aim of the current study was to evaluate the efficiency of a novel DNA vaccine encoding Mtb32C-HBHA antigen in inducing specific immune responses...

background: toll like receptors (tlrs) are well recognized players in inflammatory conditions. among them tlr-4 is involved in chronic inflammatory processes such as formation of atherosclerotic plaques. objective: the present study was aimed to examine the effects of percutanoeus coronary intervention (pci) as a revascularization method on monocyte expression of htlr-4 and on the serum levels ...

Systemic sclerosis (SSc) is a connective tissue disease characterized by autoimmunity, vasculopathy, and fibrosis. Several studies demonstrated the involvement of various cytokines including IL-1 in SSc. IL-36 cytokines, subgroup family, comprise IL-36α, β, γ, IL-36Ra, IL-38. γ are known to promote inflammatory response, which mainly produced epithelial cells. Whereas, IL-36Ra as well IL-38 may...

cytokines have been introduced as critical inducers in the development of th subpopulations.cytokines like il-10 are involved in inducing regulatory t cells such as type 1 regulatory t (tr1) cells cells. il-22 is a member of il-10 family of cytokines, and il-28a is a member of ifn-γ family. in this study, cord blood mononuclear cells (cbmc) from normal healthy individuals were isolated by ficol...

Background and aims: Interleukin-10 (IL-10) is an anti-inflammatory cytokine, and its expression is increased in rheumatoid arthritis (RA). A number of novel cytokines have been found recently, which have been designated as the IL-10 family based on their genetic characteristics. These cytokines include IL-19, IL-20, IL-22, IL-24 and IL-26. Information concerning the expression and function of ...

Objective(s): P2X4R is expressed in immunocyte and lung tissues. It has been a focus in inflammatory responses recently. This study investigated whether blockage of P2X4R attenuates allergic inflammation by modulating T cell response in ovalbumin-sensitized mice. Materials and Methods: Ovalbumin was used to sensitize and challenge for a mouse model. Intranasal application of 5-BDBD, P2X4R antag...

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease characterized by massive immune cell infiltrate, extensive fibrosis, and tissue destruction. We aimed to elucidate the role of fibroblasts in pathophysiology HS. Single-cell RNA-sequencing was performed on chronic lesional samples 6 HS patients 7 controls. Spatial sequencing 4 samples. Fibroblast subclustering revealed subset...