objective: atorvastatin has the pleiotropic effects, including anti-inflammation and antioxidant. therefore, this study considered to examine the effects of atorvastatin on nf-қb expression, as a main transcription factor for expression of inflammatory cytokines, in hyperglycemia-induced nephropathy in rat. materials and methods: twenty four male wistar rats were randomly divided into four grou...

allergic rhinitis  (ar) is  an  inflammatory  disorder  of  the  nasal  mucosa  with  high morbidity and prevalence. natural killer (nk) cells might have a role in ar. we aimed to evaluate the changes of the markers and receptors on nk cells in ar patients compared to the non-atopic controls. flow  cytometric  analysis was  used  with  double  staining  of  the  peripheral  blood mononuclear ce...

PURPOSE To determine the effects of proinflammatory cytokines on differential gene expression profiles in the human corneal endothelium (HCE), by using a cDNA expression array. METHODS A human cDNA expression array technology was used to study the simultaneous expression of HCE incubated with interleukin (IL)-1alpha and tumor necrosis factor-(TNF)-alpha. Gene-specific semiquantitative reverse...

patients and methods in total, 98 samples in four groups (hiv-positive and hiv-negative persons with and without oc) were obtained from the oral cavities and cultured on sabouraud’s dextrose agar and chromagar. also blood samples were obtained to assess plasma level of ifn-γ, il-4, il-6 and il-17 using elisa technique. background cell-mediated immunity (cmi) by cd4 + th (t helper)-type cells is...

vitiligo is a pigmentation disorder in which inflammatory mediators such as cytokines have a pivotal role in disease's pathogenesis. interleukin 17 (il-17a) is a proinflammatory cytokine which is involved in the induction of several proinflamatory mediators such as cyclooxygenase 2 (cox2). the aim of this study was to investigate the gene expression of il-17 and cox2 in peripheral blood leukocy...

In Hashimoto’s thyroiditis (HT), oxidative stress (OS) is driven by Th1 cytokines’ response interfering with the normal function of thyrocytes. OS results from an imbalance between excessive production reactive oxygen species (ROS) and a lowering antioxidant production. Moreover, has been shown to inhibit Sirtuin 1 (SIRT1), which able prevent hypoxia-inducible factor (HIF)-1α stabilization. The...

Betacellulin (BTC) is a peptide ligand that belongs to the epidermal growth factor family, members of which are implicated in skin morphogenesis, homeostasis, repair, and angiogenesis; however, role BTC regulation barrier remains unknown so far. To examine function, we analysed data from two independent Gene Expression Omnibus (GEO) datasets evaluated effects on primary human keratinocytes usin...

Background/Aim. Chronic microbial infections of the root canal are a common issue. This process very often causes an immune reaction in system that results forming chronic periapical lesions (PLs). The aim this study was to determine quantitative expression bacterial heat shock protein (HSP), chaperonin 60 (cpn60), and pro-inflammatory anti-inflammatory cytokines tissue obtained from individual...

Introduction Psoriasis is a recurrent, chronic inflammatory skin disease with complex pathogenesis. The imposes heavy burden on patients. Interleukin (IL)-36γ belongs to the IL-36 family and predominantly expressed by epithelial cells. IL-36γ upregulated in psoriasis lesions. However, effects of keratinocytes remain unclear. Material methods Eighteen IL-36γ-deficient mice were divided into thre...