Recent years have seen cytoskeleton dynamics emerging as a key player in axon regeneration. The cytoskeleton, in particular microtubules and actin, ensures the growth of neuronal processes and maintains the singular, highly polarized shape of neurons. Following injury, adult central axons are tipped by a dystrophic structure, the retraction bulb, which prevents their regeneration. Abnormal cyto...

Symbiotic rhizobium–legume interactions, such as root hair curling, rhizobial invasion, infection thread expansion, cell division and proliferation of nitrogen-fixing bacteroids, nodule formation, involve extensive membrane synthesis, lipid remodeling cytoskeleton dynamics. However, little is known about these membrane–cytoskeleton interfaces related genes. Here, we report the roles a major pho...

Mitochondrial function is dependent upon mitochondrial structure which is in turn dependent upon mitochondrial dynamics, including fission, fusion, and motility. Here we examined the relationship between mitochondrial dynamics and the cytoskeleton in Dictyostelium discoideum. Using time-lapse analysis, we quantified mitochondrial fission, fusion, and motility in the presence of cytoskeleton dis...

Inorganic nanoparticles have emerged as an attractive theranostic tool applied to different pathologies such cancer. However, the increment in inorganic nanoparticle application biomedicine has prompted scientific community assess their potential toxicities, often preventing them from entering clinical settings. Cytoskeleton network and related adhesomes nest are present most cellular processes...

A new study presents a quantitative biophysical model of microtubule aster growth with autocatalytic microtubule nucleation. The model accounts for asters that grow indefinitely, even when their microtubules are unstable.

Cells can crawl, self-heal, and tune their stiffness due to remarkably dynamic cytoskeleton. As such, reconstituting networks of cytoskeletal biopolymers may lead a host active adaptable materials. However, engineering such materials with precisely tuned properties requires measuring how the dynamics depend on network composition synthesis methods. Quantifying is challenged by variations across...

Abstract Developing tissues need to pattern themselves in space and time. A prevalent mechanism achieve this are pulsatile active stresses generated by the actin cytoskeleton. Active gel theory is a powerful tool model dynamics of cytoskeletal formation. In theoretical models, influence viscoelastic nature cytoskeleton has so far only been investigated incorporation one relaxation time scale. H...