objective: grape virus diseases are a serious problem in iran. leaves and fruits of grape have been used for different purposes like cooking in iran. the present investigation was carried out to study on the cytotoxic-activities of extracts of fruits and leaves of vitis vinifera from both virus-free and virus-infected grape cultivars against breast cancer cell line (mda-mb-231) and human embryo...

background: numerous molecules in papaveraceae family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few cases. objective: numerous molecules in this family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few...

ferula communis l., subsp. communis, namely giant fennel, has extensively been used in traditional medicine for a wide range of ailments. fresh plant materials, crude extracts and isolated components of f. communis showed a wide spectrum of in vitro and in vivo pharmacological properties including antidiabetic, antimicrobial, antiproliferative, and cytotoxic activities. the present paper, revie...

cancers belong to a group of disorders which are very important for researchers.  because they have several types and cause mortality in human beings. many  investigations are performing in order to introduce cheaper drugs with lower side  effects especially with natural sources. ferula genus grows all over the world but  some of them are endemic to iran. many investigations have proved differe...

The objective of the study was to evaluate the cytotoxic effects of aqueous extract of Cucumis melo fruit on human prostate cancer cell line (PC-3) using MTT and neutral red assays. The crude aqueous extract of C. melo was prepared by cold maceration method, filtered, concentrated and tested on PC-3 cell line. Dose-dependent cytotoxic activities were exhibited on human prostate carcinoma PC...

Background: Essential oils are found to have multiple active components which can show in vitro cytotoxic action against various cancerous cell lines. This study reports the in vitro cytotoxic effects of the essential oil from Artemisia absinthium L. (Asteraceae) growing wild in Iran. Methods: Water-distilled essential oil of A. absinthium collected from Ardabil, north-western Iran, was examin...

Purpose: To determine the cytotoxic and antiviral potentials of Euphorbia milii var. splendens leaf against Peste des petits ruminants virus (PPRV).
 Methods: The methanol extract, as well n- hexane, chloroform, ethyl acetate, butanol fractions E. leaves were screened for activities PPRV using Vero cell line 3-(4,5-dimethylthiazol-2-yl)-2,diphenyltetrazolium bromide (MTT) assay.
 Resu...

cell-based biosensors have become a research hotspot in biosensors and bioelectronics fields. the main feature of cell-based biosensors is the immobilization of living cell on the surface of transducers. different types of polymers which are used as scaffolds for cell growth should be biocompatible and have reactive functional groups for further attachment of biomolecules. in this work, the cel...

objective: the use of bacterial plasmids carrying specific genes of pathogens as genetic vaccines is a relatively new technique for induction of cellular immune responses against microbial pathogens. mechanisms of production of specific immune responses against these vaccines are not still completely understood. therefore, it is necessary to examine various routes of inoculation to find the bes...