sophora pachycarpa schrenk ex c.a.mey. belongs to the family fabaceae. some species of the genus sophora have shown to possess anti-proliferative and apoptosis-inducing activites in cancer cells. however, there is no available information addressing this effect in s. pachycarpa. here, we investigated the cytotoxic effects of methanol extract and different fractions obtained from s. pachycarpa r...

conclusions the clinical klebsiella strains isolated from lahore region, pakistan exhibited resistance to most commonly used antibiotics, which can be a serious threat to public health. the study reported some potential actinomycetes strains, which exhibit promising activity against multidrug resistant klebsiella strains. results the isolated klebsiella strains showed resistance against most of...

there have been efforts to overcome the problem in treatment of cancer using medicinal plants. it has been shown that citrus essential oil of contains different terpens with antitumor activities. in this study we sought to determine the cytotoxicity of essential oils of iranian citrus limon (l.), c. medica (l.), c. sinsensis (l.) peels on cancer cell lines. essential oils were prepared by hydro...

background and aims. since intracanal medicaments can affect the cell viability in periapical tissues, the aim of this study was to evaluate the effect of calcium hydroxide and propolis on pulp fibroblasts. materials and methods. two healthy third molars were used as a source to obtain fibroblasts. the fibroblasts were cultured and subjected to 1 mg/ml of propolis and calcium hydroxide. this ex...

objective(s): although viral vectors are considered efficient gene transfer agents, their board application has been limited by toxicity, immunogenicity, mutagenicity and small gene carrying capacity. non-viral vectors are safe but they suffer from low transfection efficiency. in the present study, polyallylamine (paa) in two molecular weights (15 and 65 kda) was modified by alkane derivatives ...

objective: scutellaria (lamiaceae) has been implicated for medicinal purposes both in modern and traditional medicine. some species of the genus scutellaria has extensively been studied for anticancer activity. scutellaria luteo-coerulea (s. luteo-coerulea) is one of the iranian species of the genus scutellaria. materials and methods: in the present study, cytotoxic and apoptogenic properties o...

recently there has been fabulous excitement in the nano-biotechnological area for the study of nanoparticles synthesis using some natural biological system, which has led the growth advanced nanomaterials. this intention made us to assess the biologically synthesized silver nanoparticles from the leaf of suaeda monoica (s.monoica) using 1 mm silver nitrate. the leaf extract of s.monoica incubat...

background: numerous molecules in papaveraceae family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few cases. objective: numerous molecules in this family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few...

doxorubicin is a broad spectrum antibiotic used in the treatment of cancers. its dose dependent cardiotoxicity is the most serious side effect causing withdrawal of drug from hard chemotherapeutic regimen. statins are shown to be cytotoxic in concentrations higher than the effective doses for the treatment of hypercholesterolemia (40 mg/day). co-administration of statins and chemotherapeutic ag...

introduction: the aim of this study was to compare the cytotoxicity of proroot mta (pmta), root mta (rmta) and portland cement (pc) on human gingival fibroblasts (hgfs). materials and methods: the extracts of the test materials were placed close to human gingival fibroblasts (hgfs) within 96-well plates. cellular viability was assessed using mtt assay in different intervals (freshly mixed, 4, 2...