Both Aroclor mixtures and individual non-coplanar polychlorinated biphenyl (PCB) congeners reduce dopamine (DA) concentrations in cells in culture and in the brains of developing and adult laboratory animals. These reductions may involve inhibition of the dopamine transporter (DAT) and the vesicular monoamine transporter (VMAT) responsible, respectively, for the uptake of extracellular DA and t...

Luane Margarete Zanchetta Marilisa Berti de Azevedo Barros Chester Luiz Galvão César Luana Carandina Moisés Goldbaum Maria Cecília Goi Porto Alves I Departamento de Medicina Preventiva e Social da Faculdade de Ciências Médicas da Universidade Estadual de Campinas UNICAMP. II Departamento de Epidemiologia da Faculdade de Saúde Pública da Universidade de São Paulo – USP. III Departamento de Saúde...

*Departamento de Quı́mica da Universidade da Beira Interior, Rua Marquês d’Ávila e Bolama, 6200 Covilhã, Portugal Instituto de Farmacologia e Terapêutica Experimental da Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal Serviço de Bioquı́mica da Faculdade de Farmácia da Universidade do Porto, Porto, Portugal §Instituto de Biologia Molecular e Celular da Universidade do Porto, Po...

Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo – USP – Ribeirão Preto (SP), Brasil. 1 Professora Doutora do Departamento de Ginecologia e Obstetrícia da Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo – USP – Ribeirão Preto (SP), Brasil. 2 Mestrando...

Dopamine (DA) release varies within subregions and local environments of the striatum, suggesting that controls intrinsic and extrinsic to the DA fibers and terminals regulate release. While applying fast-scan cyclic voltammetry and using tonic and phasic stimulus trains, we investigated the regulation of DA release in the dorsolateral to ventral striatum. The ratio of phasic-to-tonic-evoked DA...

Effects of cations on dopamine (DA) uptake into cells expressing the human dopamine transporter and on inhibition of DA uptake by various substrates and inhibitors were investigated by using rotating disk electrode voltammetry. The Na(+) dependence of DA uptake varied with Na(+) substitutes, hyperbolic with Li(+), almost linear at 1 microM DA but hyperbolic at 8 microM DA with choline, and sigm...

originating from vygotsky’s sociocultural theory, dynamic assessment (da) proposes a novel approach to second language acquisition (sla) research according to which a dialectical relationship is envisaged between instruction and assessment. although da has been applied to some areas of sla, there are areas, such as interlanguage pragmatics (ilp), that have been neglected.  to address the issue,...

DCC (deleted in colorectal cancer), a receptor for the axon guidance cue netrin-1, is highly expressed by mesencephalic dopaminergic (DA) neurons during development; however, the contribution of DCC to DA development remains largely uncharacterized. DA neurons in ventral mesencephalic nuclei also express UNC5 homologue netrin receptors from late embryogenesis to adulthood, raising the possibili...

Dopamine (DA) autoreceptors expressed along the somatodendritic extent of midbrain DA neurons modulate impulse activity, whereas those expressed at DA nerve terminals regulate both DA synthesis and release. Considerable evidence has indicated that these DA autoreceptors are of the D2 subtype of DA receptors. However, many pharmacological studies have suggested an autoreceptor role for the DA D3...

1. Instituto História da Arte da Faculdade de Letras da Universidade de Lisboa (IHA-FLUL), Laboratório de Conservação e Restauro José de Figueiredo do Instituto dos Museus e da Conservação (LCRJF-IMC), Lisbon, Portugal 2. Instituto Superior Técnico, Technical University of Lisbon, INESC-ID, Lisbon, Portugal 3. Laboratório de Conservação e Restauro José de Figueiredo do Instituto dos Museus e da...