A chromatographic method was implemented and validated for the simultaneous determination of antimicrobials proposed for the treatment of mycetoma: three fluoroquinolones: ciprofloxacin, moxifloxacin and sparfloxacin; two oxazolidinones: DA-7157 (DA2; torezolid) and its prodrug DA-7218 (DA1). Separation of analytes was achieved on an Atlantis dC18 column (150 × 4.6 mm i.d., 5 µm particle size) ...

Procedures to lesion dopamine (DA) neurons innervating the rat caudate-putamen (CP) in a partial, graded fashion are described in this study. The goal is to provide a lesion model that supports intra-animal comparisons of voltammetric recordings used to investigate compensatory adaptation of DA neurotransmission. Lesions exploited the topography of mesostriatal DA neurons, microinjections of th...

Methylmercury (MeHg) produces significant increases in the spontaneous output of dopamine (DA) from rat striatal tissue. The mechanism through MeHg produces such increase in the extracellular DA levels could be due to increased DA release or decreased DA uptake into DA terminals. One of the aims of this study was to investigate the role of DA transporter (DAT) in the MeHg-induced DA release. Co...

Striatal dopamine (DA) transmission regulates motivation and action selection through the basal ganglia. Disruptions to DA signaling underlie a variety of common psychomotor disorders, including addiction disorders and Parkinson's disease. However, we require a better knowledge of the mechanisms that govern striatal DA transmission if we are to understand DA function and dysfunction fully. Acti...

Methamphetamine (MA) produces selective degeneration of dopamine (DA) neuron terminals without cell body loss. While excitatory amino acids (EAAs) contribute to MA toxicity, terminal loss is not characteristic of excitotoxic lesions nor is excitotoxicity selective for DA fibers; rather, EAAs may modulate MA-induced DA turnover, suggesting that DA-dependent events play a key role in MA neurotoxi...

Since the hypotensive and natrluretic role recently attributed to dopamine (DA) is difficult to test (free DA is usually undetectable in plasma) we measured free and conjugated DA by a newly developed method of hydrolysis of conjugated catecholamlnes in four pheochromocytoma, four primary aldosteronism and 34 essential hypertensive patients subjected to selective venous catheterization or perip...

Massive Open Online Courses (MOOCs) as a new shaking educational development provide the scene for achieving social inclusion and dissemination of knowledge. Anyhow, facilitating network learning experiences through creating an adaptive learning environment can pave the way for this open and energetic way to learning. The present study aimed to explore the possible role of Dynamic Assessment (D...

aim : the aim of this study was to search for metabolic biomarkers of crohn’s disease (cd). background : crohn's disease (cd) is a type of inflammatory bowel disease that causing a wide variety of symptoms. cd can influence any part of the gastrointestinal tract from mouth to anus. cd is not easily diagnosed because monitoring tools are currently insufficient. thus, the discovery of proper meth...

* Recebido (Received from) do Serviço de Anestesiologia (CET/SBA) da Faculdade de Medicina da Universidade Federal de Uberlândia (FM-UFU), Uberlândia, MG. 1. Professor Doutor da Disciplina de Anestesiologia e Responsável pelo CET/ SBA da FM-UFU. Membro da Comissão de Normas Técnicas Segurança em Anestesiologia/SBA. 2. Co-Responsável pelo CET/SBA da FM-UFU. 3. Anestesiologista do Serviço de Anes...