Somatodendritic dopamine (DA) release from neurons of the midbrain represents a nonclassical form of neuronal signaling. We assessed characteristics of DA release during electrical stimulation of the substantia nigra pars compacta (SNc) in guinea pig midbrain slices. With the use of parameters optimized for this region, we compared stimulus-induced increases in extracellular DA concentration ([...

Debora Lucia Seguro Danilovic, Regina Matsunaga Martin, Pedro Caruso, Suemi Marui I Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São Paulo, Unidade de Tireoide, Endocrinology and Metabolism Department. São Paulo/SP, Brazil. II Hospital das Clı́nicas da Faculdade de Medicina da Universidade de São Paulo, Endocrinology and Metabolism Department, São Paulo/ SP, Brazil. III Hosp...

Síndrome de PiSa induzida Por aumento ráPido e doSagem elevada de riSPeridona Doutor em Ciências pelo Departamento de Psiquiatria da Faculdade de Medicina da Universidade de São Paulo, São Paulo SP, Brazil (FMUSP), Pesquisador do Instituto de Psiquiatria do Hospital das Clínicas da FMUSP; Mestre e Doutor em Ciências pelo Departamento de Psiquiatria da FMUSP, Pesquisador do Instituto de Psiquiat...

The luminescence of DNA-bound [Ru(phen)(2)dppz](2+) is shown to be highly sensitive to environmental conditions such as ionic strength, temperature, and the sequence and secondary structure of the nucleic acid, although not to bulky DNA substituents in the major groove. Each enantiomer has two characteristic lifetimes with any polynucleotide and their relative amplitudes vary as a function of b...

Circular dichroism spectroscopy (CD) sensitively reflects even slight alterations of the base stacking geometry in DNA (Tinoco et al. 1980; Johnson et al. 1981). However, the alterations cannot be unambiguously interpreted in conforma­ tional terms so that, for example, the question concerning the origin of the relatively extensive temperature-induced changes in the CD spectrum of a synthetic D...

1 Programa de Pós-Graduação em Gerontologia Biomédica. Instituto de Geriatria e Gerontologia da Pontifícia Universidade Católica do Rio Grande do Sul. 2 Programa de Pós Graduação em Bioquímica Toxicológica e Programa de Pós Graduação em Farmacologia. Departamento de Ciências da Saúde da Universidade Federal de Santa Maria. 3 Faculdade de Educação Física e Ciências do Desporto da Pontifícia Univ...

1Ophthalmology and Otorhinolaryngology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo USP – São Paulo (SP), Brazil. 2Ophthalmology and Otorhinolaryngology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo USP – São Paulo (SP), Brazil. 3Head of Strabismus Department. Ophthalmology and Otorhinolaryngology Department, H...

We have induced a local conformational transition by positive torsional stress in small synthetic circular DNA molecules containing cruciforms with immobile or tetramobile branched junctions. The immobile species correspond to the extruded and intruded extrema of the tetramobile junction. Under normal conditions the sequences of all the branched species prevent them from being re-absorbed into ...

F1 rats primed with normal parental strain lymphocyte populations and restimulated in culture with parental lymphoblasts generate potent cytotoxic T cell responses to unusual antigen systems. Here we describe in the Lewis (L)/DA anti-DA combination an antigen system most likely of mitochondrial origin with the following properties: it is transmitted maternally from DA strain females, inherited ...