it has been estimated that more than 1.7 million individuals suffer a traumatic brain injury (tbi) each year. tbi causes secondary biochemical and metabolic changes which contribute to subsequent tissue damage and associated neuronal cell death. two early and delayed events occur after tbi, which results in neurological deficits. primary injury events include the mechanical damage that occur at...

The molecular mechanisms involved in human aging are complicated. Two progeria syndromes, Werner's syndrome (WS) and Hutchinson-Gilford progeria syndrome (HGPS), characterized by clinical features mimicking physiological aging at an early age, provide insights into the mechanisms of natural aging. Based on recent findings on WS and HGPS, we suggest a model of human aging. Human aging can be tri...

traumatic brain injury (tbi) is one of the leading causes of death in men under the age of 35 that mostly occurs due to the road accidents. current clinical treatments have not enough repair and prevention of secondary damage caused by cytotoxicity. progesterone, as a primary sex hormone, acts as neuroprotection in tbi and stroke. progesterone increases anti-oxidants and decreases inflammation ...

Introduction: By introducing of laser systems and their continuous development, a new chapter of laser systems applications in a variety fields including research and clinical science in addition to the therapeutic, diagnostic applications were available for medical professionals in various fields. Most lasers emit radiation with intrinsic probable risks where in laser-tissue i...

Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2’-deoxyguanosine (8-OHdG) mutagenicity. OGG1-Cys326 gene polymorphism may decrease DNA repair function, causing oxidative stress due to higher oxidative DNA damage. The main purpose of this stu...