On the North American Great Plains, several snake species reach their northern range limit where they rely on sparsely distributed hibernacula located in major river valleys. Independent colonization histories for the river valleys and barriers to gene flow caused by the lack of suitable habitat between them may have produced genetically differentiated snake populations. To test this hypothesis...

Genetic variations in a species across geographic areas typically exhibit spatial clines. There is increasing interest inferring population genetic structure to understand the patterns of variation and evolution species. Here, we present da package propose infer using discriminant analysis (DA). We incorporate five supervised learning approaches (DAPC, LDAKPC, LFDA, LFDAKPC KLFDA) into within s...

Japanese plum (Prunus salicina Lindl.) is widely distributed in temperate zones across the world. Since its introduction to USA late 19th century, this species has been hybridized with up 15 different diploid Prunus species. This high level of introgression resulted a wide range traits and agronomic behaviors among currently grown cultivars. In work, 161 plum-type accessions were genotyped usin...

Abstract The spotted rose snapper, Lutjanus guttatus, is an important fishery species with high potential for aquaculture. Genetic characterization of its natural populations necessary to avoid stock collapse and loss genetic diversity. Previous studies carried out in the Tropical Eastern Pacific (TEP), however, have shown contrasting results structure fish populations, particularly Lutjanidae....

African trypanosomes of the sub-genus Trypanozoon) are eukaryotic parasitesthat cause disease in either humans or livestock. The development of genomic resources can be of great use to those interested in studying and controlling the spread of these trypanosomes. Here we present a large comparative analysis of Trypanozoon whole genomes, 83 in total, including human and animal infective African ...

Astrocytic endfeet are specialized cell compartments whose important homeostatic roles depend on their enrichment of water and ion channels anchored by the dystrophin associated protein complex (DAPC). This protein complex is known to disassemble in patients with mesial temporal lobe epilepsy and in the latent phase of experimental epilepsies. The mechanistic underpinning of this disassembly is...

We previously conducted a proof of principle; dose escalation study in Duchenne muscular dystrophy (DMD) patients using the morpholino splice-switching oligonucleotide AVI-4658 (eteplirsen) that induces skipping of dystrophin exon 51 in patients with relevant deletions, restores the open reading frame and induces dystrophin protein expression after intramuscular (i.m.) injection. We now show th...

The dystroglycan complex contains the transmembrane protein β-dystroglycan and its interacting extracellular mucin-like protein α-dystroglycan. In skeletal muscle fibers, the dystroglycan complex plays an important structural role by linking the cytoskeletal protein dystrophin to laminin in the extracellular matrix. Mutations that affect any of the proteins involved in this structural axis lead...

Endemic species on islands are considered at risk of extinction for several reasons, including limited dispersal abilities, small population sizes, and low genetic diversity. We used mitochondrial DNA (D-Loop) and 17 microsatellite loci to explore the evolutionary relationship between an endemic anemonefish, Amphiprion mccullochi (restricted to isolated locations in subtropical eastern Australi...

Anthropogenic actions have affected marine species for a long time, through overexploitation of natural stocks and habitat degradation, influencing the life strategies several taxa, especially rays sharks, which suffered significant population declines in recent years. Therefore, conservation stock management become paramount. In this regard, chola guitarfish, Pseudobatos percellens, distribute...