Mucin 1 (MUC1) is a tumor-associated antigen that is overexpressed in several adenocarcinomas. However, clinical trials with MUC1 showed that MUC1 is a relatively poor immunogen in humans. In view of the low immunogenicity of this protein vaccine, we designed a method based on an immunoadjuvant and immunization strategy to enhance the cellular immune response to this protein vaccine. DDA/MPL ha...

2'-beta-Fluoro-2',3'-dideoxyadenosine (F-ddA, lodenosine) is a nucleoside analog that was rationally designed as a more chemically and enzymatically stable anti-AIDS drug than its parent compound 2', 3'-dideoxyadenosine or didanosine. Plasma and cerebrospinal fluid (CSF) pharmacokinetics of this compound and its major metabolite, 2'-beta-fluoro-2',3'-dideoxyinosine (F-ddI), were studied in thre...

The potential of visible/near infrared spectra as a method of nondestructive discrimination of various rapeseed cultivars was evaluated, discrimination ability of distance discriminant analysis (DDA) and BP neural network (BPNN) for identification of rapeseed cultivars was shown in this article. The spectral curves ranging from 350 to 2500 nm of rapeseed cultivars were obtained by VIS/NIR spect...

User experience of video streaming could be greatly improved by selecting a high-yet-sustainable initial video bitrate, and it is therefore critical to accurately predict throughput before a video session starts. Inspired by previous studies that show similarity among throughput of similar sessions (e.g., those sharing same bottleneck link), we argue for a cross-session prediction approach, whe...

2'-Fluoro-2'3'-dideoxyarabinosyladenine (F-ddA), a nucleoside reverse transcriptase inhibitor of human immunodeficiency virus (HIV) replication, is currently being evaluated in clinical trials. Future monotherapy for the treatment of HIV is unlikely owing to the rapid emergence of drug-resistant viruses, so F-ddA was evaluated in combination with a variety of mechanistically diverse inhibitors ...

Interactions between helicases and the tracking strand of a DNA substrate are well-characterized; however, the role of the displaced strand is a less understood characteristic of DNA unwinding. Dda helicase exhibited greater processivity when unwinding a DNA fork compared to a ss/ds DNA junction substrate. The lag phase in the unwinding progress curve was reduced for the forked DNA compared to ...

Locally resonant metamaterials (LRMs), with unit-cells exhibiting local resonance, present extraordinary wave propagation properties as a result of their spatial periodicity. However, these structures certain limitations when wide bandgaps are sought, such the need heavy resonating masses. In this paper, simple dynamic directional amplification (DDA) mechanism is proposed means to artificially ...

Insect-derived chitin and chitosan have gained interest as alternative sources to that derived from crustaceans; however, little information is available on the house cricket (Acheta domesticus) tropical banded (Gryllodes sigillatus), two species commonly reared in United States for human consumption. In this study, was successfully isolated purified these species; using FTIR, chitins were foun...

Drug repositioning, discovering new indications for existing drugs, is known to solve the bottleneck of drug discovery and development. To support a task many in silico methods have been proposed predicting drug-disease associations. A meta-path based approach, which extracts network-based information through paths from disease, can produce comparable performance with less required when compare...