The DDT i nh ibition of (Na+, K+) a ctivated ATPase in gill pre parations of the euryhaline teleost , Fundulus heteroclitus, was measured. The (Na+, K+) -activate d ATPase was found to be sensitive to DDT, with 74.6% of the e nzyme's specific activity inhibited by 20 ppm DDT . The (Mg++)-activated ATPase was also sensitive to inhibition bv DDT but not to the extent of the (Na+, K+) activat ed A...

AIM To describe lesions resembling optic disc duplication and highlight their unusual visual fields. The authors also report the first case of pseudo-duplication of the optic disc with overlying retinal nerve fibre layer. METHODS Retrospective, non-comparative review of case notes. Humphrey visual fields and OCT-3 imaging were performed. RESULTS All 11 cases represented peripapillary chorio...

The development of resistance to insecticides has become a classic exemplar of evolution occurring within human time scales. In this study we demonstrate how resistance to DDT in the major African malaria vector Anopheles gambiae is a result of both target-site resistance mechanisms that have introgressed between incipient species (the M- and S-molecular forms) and allelic variants in a DDT-det...

Estrogenic pesticides such as DDT and chlordecone generate deleterious reproductive effects. An "in culture" bioassay was used to assess the estrogenicity of several pesticides. The E-screen test uses human breast estrogen-sensitive MCF7 cells and compares the cell yield achieved after 6 days of culture in medium supplemented with 5% charcoal-dextran stripped human serum in the presence (positi...

<Anopheles culicifacies is a main malaria vector in southeastern part of Iran, bordring Afghanistan and Pakistan. So far, resistance to DDT, dieldrin, malathion and partial tolerance to pyrethroids has been reported in An. stephensi, but nothing confirmed on resistance status of An. culicifacies in Iran. Methods: In current study, along with WHO routine susceptibility test with DDT (4%), di...

Two recent articles in EHP (1,2) and the latest Agency for Toxic Substances and Disease Registry toxicologic profile for DDT (3) make repeated references to DDT risks. These statements of risk, like so many others, are one-sided and give no consideration to colossal increases in diseases previously controlled with DDT. Behind disease statistics are grievous human tragedies, as with the case of ...

Aedes albopictus collected from urban districts of China (12 strains) has developed high levels of DDT resistance, while 2 strains collected from rural areas remain susceptible. The mechanism of DDT resistance was due to intensified activity of DDT-dehydrochlorinase, but the penetration of DDT into the mosquito body is also different. This may possibly have had some influence on the resistance ...