BACKGROUND Deficits in motivated behavior and decision-making figure prominently in the behavioral syndrome that characterizes schizophrenia and are difficult both to treat and to understand. One explanation for these deficits is that schizophrenia decreases sensitivity to rewards in the environment. An alternate explanation is that sensitivity to rewards is intact but that poor integration of ...

Cocaine abusers demonstrate faulty decision-making as manifested by their inability to discontinue self-destructive drug-seeking behaviors. The orbitofrontal cortex (OFC) plays an important role in decision-making. In this preliminary study we tested whether 25-day-abstinent cocaine abusers show alterations in normalized cerebral blood flow (rCBF) in the OFC using PET with (15)O during the Iowa...

Simple perceptual tasks have laid the groundwork for understanding the neurobiology of decision-making. Here, we examined this foundation to explain how decision-making circuitry adjusts in the face of a more difficult task. We measured behavioral and physiological responses of monkeys on a twoand four-choice direction-discrimination decision task. For both tasks, firing rates in the lateral in...

The aims of this study were to investigate choking susceptibility in a perceptual judgment task and to examine the predictive validity of the Decision Specific Reinvestment Scale (DSRS). A computer-based, choice response time basketball passing task was performed under low and high pressure conditions. Complexity was manipulated by depicting 3-on-3 and 5-on-5 scenarios. Repeated-measures ANOVAs...

Humans and animals can integrate sensory evidence from various sources to make decisions in a statistically near-optimal manner, provided that the stimulus presentation time is fixed across trials. Little is known about whether optimality is preserved when subjects can choose when to make a decision (reaction-time task), nor when sensory inputs have time-varying reliability. Using a reaction-ti...

We investigate decision-making behaviour in all four non-human great ape species. Apes chose between a safe and a risky option across trials of varying expected values. All species chose the safe option more often with decreasing probability of success. While all species were risk-seeking, orangutans and chimpanzees chose the risky option more often than gorillas and bonobos. Hence all four spe...

Iowa Gambling Task is one of the most commonly used tools in the neuropsychological assessment of the decision making process. It was designed to assess decision making in patients with damage to their prefrontal cortex. Up to date, it has been used in studies of healthy subjects and numerous clinical populations. The aim of this paper is to enclose construction and administration of the test a...

Simple perceptual tasks have laid the groundwork for understanding the neurobiology of decision-making. Here, we examined this foundation to explain how decision-making circuitry adjusts in the face of a more difficult task. We measured behavioral and physiological responses of monkeys on a twoand four-choice direction-discrimination decision task. For both tasks, firing rates in the lateral in...

OBJECTIVE This study aims to evaluate the process of decision-making in patients with obsessive-compulsive disorder (OCD) using the Iowa Gambling Task (IGT). In addition, we intend to expand the understanding of clinical and demographic characteristics that influence decision-making. METHOD Our sample consisted of 214 subjects (107 diagnosed with OCD and 107 healthy controls) who were evaluat...