This study investigates the effects of I/P injection nano silver materials in dose 0.2, 0.4, 0.6 mg/kg B.W. for 21 days on blood parameters, cardiac and hepatic tissue histology, their functions. The results showed a significant increase parameters treated animals compared with control group. histological that alteration is more pronounced which characterized by inflammatory reaction degenerati...

Neurodegenerative diseases lead to a progressive demise of neuronal functions that ultimately results in death. Besides large variety molecular pathways have been linked the degeneration neurons, dysfunctions microtubule cytoskeleton are common features many human neurodegenerative disorders. Yet, it is unclear whether causative, or mere bystanders disease progression. A so-far little explored ...

Simultaneous localization and mapping (SLAM) is the key technology for automation of intelligent mining equipment digitization environment. However, shotcrete surface symmetrical roadway in underground coal mines make light detection ranging (LiDAR) SLAM prone to degeneration, which leads failure mobile robot mapping. To address these issues, this paper proposes a robust LiDAR method detects co...

PURPOSE Retinitis pigmentosa (RP) is a blinding disease caused by the degeneration of photoreceptors. To further understand the process of degeneration in RP, the authors have traced activation patterns associated with rod and cone photoreceptor degeneration in a mouse model of RP METHODS: The authors used a double-mutant mouse, Rd-FTL, which contains a natural mutation, rd1, affecting the rod ...

Axon degeneration is an active, tightly controlled and versatile process of axon segment self-destruction. Although not involving cell death, it resembles apoptosis in its logics. It involves three distinct steps: induction of competence in specific neurons, triggering of degeneration at defined axon segments of competent neurons, and rapid fragmentation and removal of the segments. The mechani...

In the retinal degeneration B (rdgB) mutant of Drosophila, the major class of photoreceptors degenerate when the fly is raised in the light for several days; raising the fly in the dark largely prevents the degeneration. Thus, the rdgB is a conditional mutant that requires the operation of some stages of the phototransduction cascade to express its characteristic phenotype. We report here exper...

This review focuses on recent developments in our understanding of neurodegeneration at the mammalian neuromuscular junction. We provide evidence to support a hypothesis of compartmental neurodegeneration, whereby synaptic degeneration occurs by a separate, distinct mechanism from cell body and axonal degeneration. Studies of the spontaneous mutant Wld(s) mouse, in which Wallerian degeneration ...

UNLABELLED Calcium is a key regulator of axon degeneration caused by trauma and disease, but its specific spatial and temporal dynamics in injured axons remain unclear. To clarify the function of calcium in axon degeneration, we observed calcium dynamics in single injured neurons in live zebrafish larvae and tested the temporal requirement for calcium in zebrafish neurons and cultured mouse DRG...

Background: The neuroprotective effects of duloxetine, as an antidepressant agent, and the neurodegenerative effects of methamphetamine have been shown in previous studies. Nonetheless, their exact neurochemical and behavioral effects are still unclear. In the current study, we sought to clarify the molecular mechanisms involved in the protective effects of duloxetine against methamphetamine-in...