This paper reports on four cases of a specific type of cerebellar degeneration which suggests an arrest of cerebellar development at an early foetal stage. Histochemical and silver stain studies were necessary to demonstrate some of the more characteristic features which strikingly distinguished this type of degeneration from the granular layer type of cerebellar degeneration or the common type...

BACKGROUND Sagittal spinopelvic alignment changes associated with degenerative facet joint arthritis have been assessed in a few studies. It has been documented that patients with facet joint degeneration have higher pelvic incidence, but the relationship between facet joint degeneration and other sagittal spinopelvic alignment parameters is still disputed. Our purpose was to evaluate the corre...

BACKGROUND Osteoarthritis (OA) is a progressive degenerative condition of synovial joints in response to both internal and external factors. The relationship of OA in one joint of an extremity to another joint within the same extremity, or between extremities, has been a topic of interest in reference to the etiology and/or progression of the disease. METHODS The prevalence of articular carti...

Introduction: Cerebellar degeneration has been associated in patients with epilepsy, though the exact pathogenic mechanisms are not understood. The aim of this systematic review was to identify prevalence cerebellar epilepsy and any mechanisms. Methodology: A computer-based literature search conducted using PubMed database. Data extracted included prevalence, clinical, neuroradiological, neurop...

BACKGROUND The purpose of this prospective study was to examine the progression of fatty muscle degeneration over time in asymptomatic shoulders with degenerative rotator cuff tears. METHODS Subjects with an asymptomatic rotator cuff tear in 1 shoulder and pain due to rotator cuff disease in the contralateral shoulder were enrolled in a prospective cohort. Subjects were followed annually with...

STUDY DESIGN A literature review. OBJECTIVE To synthesize the scientific literature on the prevalence of lumbar disc degeneration and factors associated with its occurrence, including genetic influences. METHODS A literature review was conducted of the prevalence of disc degeneration. Studies of the etiology of disc degeneration were summarized, with particular attention given to studies of...

AIM Exploring the relationship between two polymorphisms (MMP-1-755 T/G [rs498186] and MMP-3 A/C [rs632478]) and disc degeneration. MATERIAL AND METHODS We performed a case-control study on 130 cases with intervertebral disc degeneration confirmed by Magnetic Resonance Imaging (MRI) and 210 healthy individuals. Schneiderman criterion was used to determine the severity of the disc degeneration...

OBJECTIVE Using alendronate after spinal fusion is a controversial issue due to the inhibition of osteoclast mediated bone resorption. In addition, there are an increasing number of reports that the endplate degeneration influences the lumbar spinal fusion. The object of this retrospective controlled study was to evaluate how the endplate degeneration and the bisphosphonate medication influence...

Wallerian degeneration is an innate immune response which occurs after some kinds of nerve damages such as neurodegenerative disease and acute axonal injury. In clinic, dexamethasone as an anti-inflammatory drug has been used for many years to treat nerve injuries. In present study, we aimed to study the effects of various doses of dexamethasone on the Wallerian degeneration in rat. Twentyseven ...

PURPOSE Loss of photoreceptor cells is associated with retinal vascular degeneration in retinitis pigmentosa, whereas the presence of photoreceptor cells is implicated in vascular degeneration in diabetic retinopathy. To investigate how both the absence and presence of photoreceptors could damage the retinal vasculature, we compared two mouse models of photoreceptor degeneration (opsin-/- and R...