background nephrotoxicity is characterized and scored by many parameters such as vacuolization, dilatation, hyaline cast, debris or degeneration in injured renal tissue. in this short report, we attempt to find, the most correlated parameters with kidney tissue pathology damage score (pds) in cisplatin-induced nephrotoxicity. method a total of 207 normal and toxic rats’ kidney tissue (induced b...

age-related macular degeneration (amd) is the leading cause of blindness in old subjects. it is a multifactorial disease with both environmental and genetic factors playing some role in its pathogenesis. similar to many other genetic diseases, the inheritance pattern of amd does not fit into simple mendelian rules. these diseases are caused by the presence of multiple genetic factors and are ca...

background: age-related macular degeneration (amd) is one of the leading causes of visual loss among people aged 65 yr and older. the pathophysiology of amd is poorly understood. the purpose of this study was to evaluate the relationship between serum lipid concentrations and age-related macular degeneration. methods: in this case-control study, total cholesterol (tch), low density lipoprotein ...

background and objectives: studies have documented the morhplogical, neurochemical and functional difference between the dorsal and ventral zones of hippocampus. the aim of this study was to assess the effects of chronic diabetes mellitus type1 on ventral and dorsal zones of hippocampus. methods: experimental diabetes was induced by stereptozotocin at a dose of 60 mg/kg. at the end of 8 weeks ...

results the mean udva (logmar) improved significantly from 1.13 ± 0.21 preoperatively to 0.24 ± 0.13 postoperatively (p < 0.001), and the mean cdva (logmar) improved significantly from 0.39 ± 0.12 to 0.19 ± 0.09 (p < 0.001). the mean cylinder of manifest refraction decreased significantly by 4.00 diopter (d) (p < 0.001). the mean spherical equivalent error (se) decreased significantly from −6.0...

background: we aimed here to investigate the association between alleles and genotypes of apoe and age-related macular degeneration (amd) development. materials and methods: after ophthalmological examination, 120 patients with confirmed amd and 120 healthy controls were enrolled in the study. the polymorphic segment of apoe gene was pcr-amplified and sequenced to determine the frequency distri...

purpose: to evaluate the clinical features, and functional and anatomical outcomes of surgical intervention for pediatric rhegmatogenous retinal detachment (rrd). methods: in this retrospective case series, pediatric patients with rrd who had undergone surgical intervention were included. cases were categorized into five main etiological groups: congenital or developmental (48 eyes), traumatic ...

purpose : to offer a semi-automatic algorithm to determine the area of angiographic hyperfluorescence methods : the proposed algorithm included wavelet filter, histogram equalization and modified otsu thresholding. hyperfluorescent area of 30 angiographic images obtained from patients with leaking choroidal neovascularization (cnv) and diabetic retinopathy were evaluated and the results were co...