BACKGROUND Osteoarthritis is a serious social problem. Young people usually present with secondary degenerative changes. These patients find it particularly difficult to accept symptoms, as they are at their peak of professional activity and family life. They have high expectations regarding improvement in life comfort. The aim of this study was to analyse clinical and radiological outcomes of ...

Cartilage degeneration is associated with degenerative bone and joint processes in severe osteoarthritis (OA). Spontaneous cartilage regeneration is extremely limited. Often the treatment consists of a partial or complete joint implant. Adipose-derived stem cell (ASC) transplantation has been shown to restore degenerated cartilage; however, regenerative differences of ASC would depend on the so...

Degenerative joint disease (DAD) or osteoarthrosis (OA) is a common among dogs and characterized by being progressive, minimally inflammatory with non-neoplastic neoproliferative alterations, which causes considerable dysfunction in all structures its subsequent failure. Affected animals present lameness, reluctance to move after rest difficulty performing certain activities, these the earliest...

OBJECTIVES To evaluate the early results of unilateral posterior lumbar interbody fusion technique in lumbar discectomy cases compared with simple discectomy and bilateral posterior interbody fusion cases using visual analog scale (VAS) and Oswestry outcomes instruments and radiological and physical examinations. METHODS The control group had 40 patients who underwent simple discectomy. In gr...

OBJECTIVE To investigate the risk factors for meniscal damage, an important determinant of knee osteoarthritis. METHODS We studied 243 men and women aged 20-59 years in whom the diagnosis of a meniscal tear was confirmed for the first time at arthroscopy, over a 25 month period, in 2 British hospitals. Each case was compared with one or 2 community controls, matched by age and sex, who were r...

LEARNING OBJECTIVES After studying this article, the participant should be able to: 1. Understand the pathomechanical and biochemical basis for thumb trapeziometacarpal joint degeneration. 2. Diagnose and grade trapeziometacarpal joint disease based on presentation, physical examination (including provocative testing), and radiographic evidence. 3. Understand the principles of ligament reconstr...

The purpose of this study was to compare the frequency of degenerative changes in the sacroiliac joint by age, sex, laterality, body mass index, and childbearing experience, based on computed tomography (CT) images obtained from the lower back of symptom-free subjects in different age groups. These data were used to trace the development of the sacroiliac joint until the occurrence of osteoarth...

Examination was made of 486 skeletons of subjects over the age of 60 years to study patterns of degenerative change in the glenohumeral joint. Three distinct types were found. Useful clinical implications are drawn from these distinctions.

A 45-year-old patient, caucasian, affected by severe, painful and invalidating rizoarthrosis has been treated by implanting autologous chondrocytes, normally used for degenerative joint diseases of the knee and ankle.

Purpose: Osteoarthritis is a prevalent degenerative joint disease with huge public health burden and no curative therapy. There clear urgent need to translate insights from genomics into better understanding of mechanisms. A hallmark osteoarthritis cartilage degradation. Here, we aim characterize molecular events in at the whole transcriptome level.