the objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (dds) for metoprolol tartarate (mt) as tablet and capsule. pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery ...

objective(s): we aimed to investigate the influence of transient receptor potential channel 3 (trpc3) on lipopolysaccharide-induced (lps) preterm delivery mice. materials and methods: mice were randomly assigned to the four groups: an unpregnant group, a mid-pregnancy group (e15), a term delivery group, and an lps-induced preterm delivery group (intraperitoneal injection lps at 15 days). uterin...

background prematurity is an issue related to increasing the neonatal morbidity and mortality and smoking pregnant women cause the risk of low birth weight and prematurity increase, compared to non-smoking ones. results of all 205 women, 43 (20.97%) women exposed to shs during pregnancy and 162 (79.02%) women did not. in shs exposure group, 11 infant (25.6%) and in non- shs exposure group, 17 i...

glioma, as a primary tumor of central nervous system, is the main cause of death in patients with brain cancer. therefore, development of an efficient strategy for treatment of glioma is worthy. the aim of the current study was to develop a srl peptide-coated dendrimer as a novel dual gene delivery system for targeting the lrp receptor, an up-regulated gene in both bbb and glioma cells. to perf...

objective polyethylenimine (pei), a readily available synthetic polycation which has high transfection efficiency owing to its buffering capacity was introduced for transfection a few years ago. but it has been reported that pei is cytotoxic in many cell lines. in this study, in order to enhance the transfection efficiency of 10 kda pei and reduce its toxicity, hydrophobic residues were grafted...

nowadays, developements in nanotechnology have leeds an increased application of this newborn technology in cancer treatment. in this study, a stabilized micelle was developed to load hpd in order to be used in photodynamic treatment of cancer in an animal model. to construct micelles, pluronic p-105 was used and stabilized to encapsulate hpd . this process includes a 24 h polymerization in whi...

background : high incidence of menstrual disorders at late ages of fertility accounts for 20% of clinical visits and 25% of gynecological surgeries. this study was conducted to identify the relationship between delivery type and menstrual disorders in women referring to hospitals affiliated to medical universities in tehran in 2008. methods : in this case-control study, which was conducted from...

since hospitals are an important and integral part of the overall health delivery system, this study was carried out to measure the effectiveness of this institution within the system. the records of 633 hospitalized patients in the pediatrics ward of ghaem hospital in mashhad during 1357 (21 march 1978-20 march 1979) has been consulted. more than half of the patients were hospitalized with the...

trauma is one of the major non-obstetric causes of pregnancy-associated maternal deaths. most cases of maternal trauma include: motor vehicle crashes, domestic violence, falls, burns, suicide, and toxic exposure. pregnancy-related anatomic and physiologic changes like increased joint laxity, weight gain, and changes in the center of gravity during pregnancy increase the risk of falling. one of ...