The dendrite of the sensory neuron is surrounded by support cells and is composed of two specialized compartments: the inner segment and the sensory cilium. How the sensory dendrite is formed and maintained is not well understood. Hook-related proteins (HkRP) like Girdin, DAPLE, and Gipie are actin-binding proteins, implicated in actin organization and in cell motility. Here, we show that the D...

Even though many extracellular factors have been identified as promoters of general dendritic growth and branching, little is known about the cell-intrinsic modulators that allow neurons to sculpt distinctive patterns of dendrite arborization. Here, we identify Lrig1, a nervous system-enriched LRR protein, as a key physiological regulator of dendrite complexity of hippocampal pyramidal neurons....

Dendritic flux penetration is a well known phenomenon in high temperature superconductors. We investigated the conditions under which this instability can be observed in different materials. We found three qualitatively different behaviors: dendrite development above a “critical field” and up to a certain temperature, above a “critical field” with no measurable temperature dependence, or no den...

<p>Let X be a local dendrite, and f : → map. Denote by E(X) the set of endpoints X. We show that if is countable, then following are equivalent:</p><p>(1) equicontinuous;</p><p>(2) <img src="data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAACoAAAA/CAYAAACW2FpzAAAE5ElEQVRoBe2af0zUZRzH4Y671FhMMtIRGhE4rc2to1JnKbOGLn8ABRTJmL8yXdPYUKkQRFpoiKekoiOSmZqbmhWIDih3MozgD8RIcKQ...

The role of dendritic spine morphology in the regulation of the spatiotemporal distribution of free intracellular calcium concentration ([Ca2+]i) was examined in a unique axial-symmetrical model that focuses on spine-dendrite interactions, and the simulations of the model were compared with the behavior of real dendritic spines in cultured hippocampal neurons. A set of nonlinear differential eq...

BACKGROUND Dendritic morphology largely determines patterns of synaptic connectivity and electrochemical properties of a neuron. Neurons display a myriad diversity of dendritic geometries which serve as a basis for functional classification. Several types of molecules have recently been identified which regulate dendrite morphology by acting at the levels of transcriptional regulation, direct i...

Layer V pyramidal cells of the somatosensory cortex operate with two spike initiation zones. Subthreshold depolarizations are strongly attenuated along the apical dendrite linking the somatic and distal dendritic spike initiation zones. Sodium action potentials, on the other hand, are actively back-propagating from the axon hillock into the apical tuft. There they can interact with local excita...

objective: the hippocampal formation, particularly the dentate gyrus (dg), shows age-related morphological changes that could cause memory decline. it is indicated that boswellia resins attenuates memory deficits and the major component of boswellia serrata (bs) gum resin, beta boswellic acid increased neurite outgrowth and branching in hippocampal neurons. this study was designed to investigat...