long-term exposure to opiates induces physical dependence and tolerance. the main goal of this study was to evaluate the effects of dextromethorphan and midazolam and their combination on morphine tolerance and dependence in mice. different groups of mice were rendered randomly and received morphine (50 mg/kg, sc), morphine (50 mg/kg, sc) + dextromethorphan (25,50 or 75 mg/kg, ip), morphine (50...

one of the most important behavioral aspects in relationship among the main members of marketing channel is the issue of power and dependence that here we have looked through the source of power and countervailing power and we have considered reputation independence, sale and profits and marketing role dependence. in this research relationship between the two main marketing channel members in h...

buprenorphine (subutex) has been used to treat opioid dependency in the past 16 years. subutex (or buprenorphine hydrochloride) was approved by the singapore's ministry of health (moh) in 2000 as a substitution treatment for opiate-dependent drug abusers within the framework of medical, social and psychological treatments. it was subsequently introduced into the singapore market in 2002. i...

results there was significant reduction in anger symptoms of drug-dependent individuals after gross model based emotion regulation training (ert) (p < 0.001). moreover, the effectiveness of the training on anger was persistent in the follow-up period. conclusions symptoms of anger in drug-dependent individuals of this study were reduced by gross model-based emotion regulation strategies trainin...

background and aims: safflower (carthamus tinctorius l.)from asteraceae family has different biological activities including analgesic, antidepressant, anti-inflammatory, antispasmodic and neuroprotective effects. this study designed to evaluate its effect on naloxone -induced morphine withdrawal signs. methods: in this experimental study, male nmri mice (25-30 g) were randomly divided into 5 g...

background several empirical studies have shown the attitude of smokers to formulate judgments based on distortion in the risk perception. this alteration is produced by the activation of the optimistic bias characterized by a set of the unrealistic beliefs compared to the outcomes of their behavior. this bias exposes individuals to adopt lifestyles potentially dangerous for their health, under...

background: 7-lif: mg,cu,p (gr-207a) is one kind of thermo-luminescent dosimeters (tld) which can be used in diagnostic radiology and radiotherapy applications. because of having suitable properties such as good sensitivity, small size and being tissue equivalent, thermo-luminescent dosimetry has been one of the most important techniques in medicine over many years. choosing a correct energy fo...

effect of otostegia persica on naloxone-induced morphine withdrawal syndrome was studied in male mice. dependence was induced using daily subcutaneous injections of morphine for three days. morphine was injected to mice at doses of 30 and 45mg/kg on day 1 and 60 and 90mg/kg on day 2 (8:00 am and 6:00 pm). on day 3, morphine (90mg/kg) was injected 1h before oral administration and 1.5h before in...

introduction : according to drug gateway theory, smoking cigarette, especially, low onset age of smoking, is one of the risk factors for future use. objective the present study deals with comparison of nicotine addicts and opiate addicts in order to identify that what differences in personality traits and onset age of smoking exist in these two groups that cause some individuals to appeal to ot...

introduction: n-methyl-d-aspartate (nmda) receptors play a pivotal role in the development of tolerance and physical dependence to opiates. activation of nmda receptors involves the induction of long term potentiation (ltp) in hippocampus. our previous study suggested that chronic oral administration of morphine enhanced nmda dependent ltp in the ca1 area of hippocampal slices of rats. the pres...