The objective of this study was to develop a novel bacterially-triggered micro-particular system of de-esterified tragacanth (DET) in combination with Eudragit S-100 coated capsules for colon drug delivery of 5-fluorouracil (5-FU) using microemulsion method. The loading study was conducted at different drug-to-polymer ratios and cross-linker concentrations. The maximum loading efficiency was ac...

the aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water/soluble drug, salbutamol sulphate by (water in oil) in oil emulsion technique using ethyl cellulose as the retardant material. various processing and formulation parameters such as drug/polymer ratio, stirring speed, volume of processing medium were optimized to maximize the e...

The ginsenoside Rg1 is the most abundant compound in ginseng. Recent studies showed that Rg1 had neuroprotective effects on neuronal cells. The present study was to prepare Rg1-loaded alginate-chitosan microspheres and research the effects of microspheres on human bone marrow (BM) stromal cells (hBMSC). The alginate-chitosan microspheres were prepared by mechanical emulsification technique in c...

Fluorescent microspheres have been demonstrated to be useful in a variety of biological applications. Fluorescent silica or polymer microspheres have been produced by incorporation of chromophores into the microspheres, which usually produces microspheres with nonuniform sizes and reduced fluorescence. Here we present a simple and straightforward method to produce silica microspheres with fluor...

In this paper, ibuprofen was encapsulated into microspheres by oil-in-water (o/w) emulsion solvent evaporation method. Biodegradable polymers with certain compositions and characteristics such as polylactide (PLA), poly(epsilon-caprolactone) (PCL) and their block copolymer were used to prepare the microspheres. The results indicate that, under the same processing conditions, the drug entrapment...

Glenny, Robb W., Susan L. Bernard, and Wayne J. Lamm. Hemodynamic effects of 15-mm-diameter microspheres on the rat pulmonary circulation. J Appl Physiol 89: 499–504, 2000.—The microsphere method has been used extensively to measure regional blood flow in large laboratory animals. A fundamental premise of the method is that microspheres do not alter regional flow or vascular tone. Whereas this ...

preparation of tretinoin-containing microspheres with the aim of reducing undesirable skin reactions towards trans retinoic acid (tra) and thus, improving patient compliance is of particular interest. these microspheres have to be smaller than 30 m m to avoid causing gritty feel when applying on the skin, and slow the release of drug to minimize its skin side effects. following preliminary eval...

Preparation of chitosan (CS) microspheres as a novel drug delivery vehicle for intranasal immunization using high, medium and low CS molecular weight (MW) was investigated in this study. Diphtheria toxoid (DT) was used as a model antigen. The emulsion-solidification method was adopted for microencapsulation of DT.  In the first step, following the purification of semi-crude DT by the ion-exchan...

Microspheres were generated after subjecting corn stem rind to highpressure water pretreatment. These microspheres can be divided into two categories according to their location: free microspheres and adsorbed microspheres. The formation and characterization of both microsphere types were studied. For the free microspheres, the maximum formation was reached at 180 °C; when the temperature was t...

In the study we formulated the serratiopeptidase loaded cholic acid conjugated and unconjugated chitosan mucoadhesive microspheres. It was observed that the conjugated microspheres show better permeation rate than unconjugated microspheres. Moreover the permeation enhancer increased the % cumulative drug permeation through the mucosal membrane from 69.37 % to 74.39 % for unconjugated microspher...