نتایج جستجو برای: dha)

تعداد نتایج: 5264  

2014
Anthony F. Domenichiello Chuck T. Chen Marc-Olivier Trepanier P. Mark Stavro Richard P. Bazinet

Docosahexaenoic acid (DHA) is important for brain function, however, the exact amount required for the brain is not agreed upon. While it is believed that the synthesis rate of DHA from α-linolenic acid (ALA) is low, how this synthesis rate compares with the amount of DHA required to maintain brain DHA levels is unknown. The objective of this work was to assess whether DHA synthesis from ALA is...

Journal: :The Journal of pharmacology and experimental therapeutics 2010
Ramzi J Khairallah Karen M O'Shea Bethany H Brown Nishanth Khanna Christine Des Rosiers William C Stanley

Intake of fish oil containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) prevents heart failure; however, the mechanisms are unclear. Mitochondrial permeability transition pore (MPTP) opening contributes to myocardial pathology in cardiac hypertrophy and heart failure, and treatment with DHA + EPA delays MPTP opening. Here, we assessed: 1) whether supplementation with both DHA a...

2010
Ramzi J. Khairallah Karen M. O’Shea Bethany H. Brown Nishanth Khanna Christine Des Rosiers William C. Stanley

Intake of fish oil containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) prevents heart failure; however, the mechanisms are unclear. Mitochondrial permeability transition pore (MPTP) opening contributes to myocardial pathology in cardiac hypertrophy and heart failure, and treatment with DHA EPA delays MPTP opening. Here, we assessed: 1) whether supplementation with both DHA and...

2013
Matthew Ouellette Andrea M. Makkay R. Thane Papke

Dihydroxyacetone (DHA) is a ketose sugar that can be produced by oxidizing glycerol. DHA in the environment is taken up and phosphorylated to DHA-phosphate by glycerol kinase or DHA kinase. In hypersaline environments, it is hypothesized that DHA is produced as an overflow product from glycerol utilization by organisms such as Salinibacter ruber. Previous research has demonstrated that the halo...

Journal: :Antimicrobial agents and chemotherapy 2014
Francisco José Pérez-Llarena Laura Zamorano Frédéric Kerff Alejandro Beceiro Patricia García Elisenda Miró Nieves Larrosa Frederic Gómez-Bertomeu José Antonio Méndez Juan José González-López Antonio Oliver Moreno Galleni Ferran Navarro Germán Bou

During a Spanish surveillance study, two natural variants of DHA β-lactamases, DHA-6 and DHA-7, were found, with the replacements Ala226Thr and Phe322Ser, respectively, with respect to DHA-1. The DHA-6 and DHA-7 enzymes were isolated from Escherichia coli and Enterobacter cloacae clinical isolates, respectively. The aim of this study was to genetically, microbiologically, and biochemically char...

Journal: :The American journal of clinical nutrition 2003
Jean-Marc Alessandri Carine Poumès-Ballihaut Bénédicte Langelier Marie-Hélène Perruchot Gilda Raguénez Monique Lavialle Philippe Guesnet

BACKGROUND Functional maturation of nervous tissues depends on membrane accretion of docosahexaenoic acid (DHA). Animal studies have shown that incorporation of dietary DHA into membrane phospholipids is dose dependent. The molecular effects of DHA are commonly studied in cultured cells, but questions remain about the physiologic connection between animal and cell models. OBJECTIVE We develop...

2014
Lin Dai Luying Wang Lihong Deng Jing Liu Jiandu Lei Dan Li Jing He

The clinical application of dihydroartemisinin (DHA) has been hampered due to its poor water-solubility. To overcome this hurdle, we devised a novel polymer-drug conjugate, multiarm polyethylene glycol-dihydroartemisinin (PEG-DHA), made by linking DHA with multiarm polyethylene glycol. Herein, we investigated PEG-DHA on chemical structure, hydrolysis, solubility, hemolysis, cell cytotoxicity in...

Journal: :Prostaglandins, leukotrienes, and essential fatty acids 2001
D R Tocher J R Dick

The desaturation of [1-(14)C] 18:3n-3 to docosahexaenoic acid (DHA; 22:6n-3) is enhanced in an essential fatty acid deficient cell line (EPC-EFAD) in comparison with the parent cell line (EPC) from carp. In the present study, the effects of DHA on lipid and fatty acid compositions, and the metabolism of [1-(14)C]18:3n-3 were investigated in EPC-EFAD cells in comparison with EPC cells. DHA suppl...

Journal: :Journal of Drug Delivery Science and Technology 2022

In this study a factorial design was used to optimize process conditions produce spray-dried powder of dihydroartemisinin (DHA) with ?-cyclodextrin (?-CD). Predicted for maximum yield and minimum residual moisture were as follows: inlet temperature; 120 °C, aspirator setting; 100%, feed rate; 25%, molar ratio DHA:?-CD; 1:2. The higher percent inclusion obtained in the lower DHA:?-CD. DHA existe...

Journal: :Japanese journal of infectious diseases 2007
Le Thi Diem Thuy Kesara Na-Bangchang Le Ngoc Hung Mieu Tieu Chong Nguyen Van Thang Nguyen Van Binh Phan Thi Danh

The clinical efficacy of the monotherapy involving the administration of a high dose of dihydroartemisinin (DHA 900 mg) for 5 days was compared with that of the combination regimen (DHA 600 mg + mefloquine [MQ] 750 mg) in an open randomized study in 90 patients with uncomplicated falciparum malaria in the southern part of Viet Nam. Patients were randomly treated with the DHA-5 day monotherapy r...

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