OBJECTIVE To investigate the effectiveness of injecting liquid silicone in the diabetic foot to reduce risk factors for ulceration in a randomized double-blind placebo-controlled trial. RESEARCH DESIGN AND METHODS A total of 28 diabetic neuropathic patients without peripheral vascular disease were randomized to active treatment with 6 injections of 0.2 ml liquid silicone in the plantar surfac...

OBJECTIVE To evaluate 1) the new ulceration, the new major amputation, and the survival rates of 115 diabetic subjects hospitalized for foot ulceration from 1990 to 1993, with an average follow-up of 6.5 years, and 2) the demographic and clinical characteristics associated with these events. RESEARCH DESIGN AND METHODS A total of 115 subjects, 31 women and 84 men, were monitored until 31 Dece...

Home monitoring of skin temperature is effective to prevent diabetic foot ulceration. We explored the validity of various definitions for the >2·2°C left-to-right threshold used as a warning signal for impending ulceration. Twenty patients with diabetes and peripheral neuropathy monitored their skin temperature with an infrared thermometer at the plantar hallux, metatarsal heads, midfoot and he...

AIMS/HYPOTHESIS Early diagnosis of diabetic polyneuropathy (DPN) is critical for a good prognosis. We aimed to identify different groups of patients, based on the various common clinical signs and symptoms of DPN, that represent a progressive worsening of the disease before the onset of plantar ulceration or amputation. We also sought to identify the most important DPN-related variables that ca...

Lower extremity complications in persons with diabetes have become an increasingly significant public health concern in both the developed and developing world. These complications, beginning with neuropathy and subsequent diabetic foot wounds frequently lead to infection and lower extremity amputation even in the absence of critical limb ischemia. In order to diminish the detrimental consequen...

1. Neurogenic inflammation, mediated by nociceptor C fibres, is part of the acute neurovascular response to injury producing the axon reflex flare. Laser Doppler flowmetry was used to measure the flare response induced by the electrophoresis, at various current strengths, of a ring of acetylcholine solution into dorsal foot skin. 2. Nineteen control subjects and 52 long-duration insulin-depende...

Background: The impact of foot ulceration on the psychosocial wellbeing Nigerian diabetic patients has not received enough attention. This study therefore attempted to evaluate effect ulcer quality life adults in a population.
 Methodology: impacts (DFU) (QoL) 104 living with diabetes were assessed using Diabetes Foot Ulcer Scale and their determinants.
 Results: mean QoL score was 42...

Diabetes mellitus is among ten leading cause of death in high-income countries and it is increasing rapidly in countries undergoing industrialization. Diabetes alone claims on the average around 8% of total health budgets in developed countries [1]. Complications include diabetic retinopathy, renal failure, heart disease, diabetic neuropathy and foot ulceration and amputation. More than 90% of ...

OBJECTIVES To delineate the epidemiology of Charcot foot in Hong Kong Chinese diabetic patients, and to provide baseline data for benchmarking the clinic service for this special group of patients. DESIGN Retrospective cohort study. SETTING Regional hospital, Hong Kong. PATIENTS Diabetic patients with Charcot foot and age- and sex-matched diabetic foot clinic attendees between 1995 and 20...