OBJECTIVE Alström syndrome, with type 2 diabetes, and blindness could confer a high risk of foot ulceration. Clinical testing for neuropathy in Alström syndrome and matched young-onset type 2 diabetic subjects was therefore undertaken. RESEARCH DESIGN AND METHODS Fifty-eight subjects with Alström syndrome (18 insulin-resistant nondiabetic and 40 diabetic; aged 8-43 years) and 30 young-onset d...

Background To avoid abnormal foot local loading while maintaining a physiological foot biomechanics does represent a challenge in the management of Diabetic foot and a valuable instrument to counter the onset of the ulceration process. The authors hypothesized that silicone socks may help in keeping dynamic peak pressures below risky values. The study describes the methodology the authors used ...

Abstract Introduction Diabetic foot ulceration is a devasting complication of diabetes contributing to significant morbidity. Delayed wound healing leads limb loss and associated stress, anxiety depression. Apart from systemic inflammatory markers qualitative assessment the ulcers, there no molecular biomarker that can help prognosticate fate diabetic ulcer. Metabonomics powerful toolset employ...

Background The Multi-disciplinary Foot Ulcer Clinic (MDFUC) at Royal Perth Hospital (RPH) is an interdisciplinary clinical team that specialises in the management of patients with chronic foot ulceration and/or infection. The MDFUC was established in 2004 and is coordinated through the RPH Podiatry Department. In 2007, an Orthopaedic surgeon with foot and ankle expertise was added to the team. ...

Management of the diabetic foot is often problematic, particularly as the diabetic patient is prone to sub-clinical infections. This article reviews diabetic foot ulceration and its treatment and describes some of the commonly associated complications of these chronic wounds. It is proposed that highly hydrophobic dressings are of value in reducing the bacterial colonization of ulcers, and an e...

Static and dynamic measurements of foot pressure have been carried out on three groups of subjects: diabetic patients with neuropathy (with and without a history of ulceration), diabetic patients with no neuropathy, and normal subjects as controls. In many cases both techniques of measurement detected areas of abnormally high pressure under the foot, but in some cases a particularly high-pressu...

OBJECTIVE The purpose of this study was to determine whether a strategy of aggressive cardiovascular risk management reduced the mortality associated with diabetic foot ulceration. RESEARCH DESIGN AND METHODS After an initial audit of outcomes demonstrating a high mortality rate in 404 diabetic foot ulcer patients with the first ulceration developing between 1995 and 1999, a new aggressive ca...

OBJECTIVE People with diabetic neuropathy are frequently prone to several bone and joint abnormalities. Simple radiographic findings have been proven to be quite useful in the detection of such abnormalities, which might be helpful not only for early diagnosis but also in following the course of diabetes through stages of reconstruction of the ulcerated foot.The present study was designed to id...

Vol. 5 (6D) n June 2005 Although the published evidence is limited, patients with diabetes mellitus are more likely to develop onychomycosis than are patients without diabetes mellitus. A study conducted by Gupta et al showed that onychomycosis is 2.8 times more prevalent among people with diabetes mellitus than in those without the disease. Diabetic neuropathy can predispose a patient to devel...