Chemokines and their receptors have been implicated in the development of diabetic nephropathy. To determine whether the risk of diabetic nephropathy is influenced by two functional polymorphisms in the regulated upon activation normal T-cell expressed and secreted (RANTES) receptor gene (CCR5), we recruited patients with type 1 diabetes, including 496 case subjects with overt proteinuria or en...

The association between subclinical hypothyroidism (SCH) and microvascular complications of type 2 diabetes is unclear. We examined whether SCH is associated with diabetic retinopathy or nephropathy in Korean patients with type 2 diabetes. Data from 489 patients who visited the diabetes clinic at a university hospital between 2001 and 2007 were analyzed retrospectively. Participants were evalua...

D iabetic nephropathy is a major complication of diabetes. In the early stage, microalbuminuria is observed and followed by massive proteinuria. In the advanced stage, renal function decreases and uremia occurs. If nephropathy progresses, hemodialysis has to be initiated. Accordingly, suppressing the progression of diabetic nephropathy is important and urgent for the patient’s quality of life. ...

AIMS We sought to determine the association between levels of adiponectin and oxidized low-density lipoprotein (ox-LDL) in patients with diabetic nephropathy as well as their effect on carotid intima-media thickness (cIMT). METHODS Adiponectin and ox-LDL were determined in 25 diabetic patients without nephropathy and 94 patients at different stages of diabetic nephropathy including subjects o...

The most problematic issue in clinical nephrology is the relentless and progressive increase in patients with ESRD (end-stage renal disease) worldwide. The impact of diabetic nephropathy on the increasing population with CKD (chronic kidney disease) and ESRD is enormous. Three major pathways showing abnormality of intracellular metabolism have been identified in the development of diabetic neph...

Diabetic nephropathy is the single most common disorder leading to renal diseases. Reactive oxygen species (ROS) play a major role in the development of diabetic nephropathy. Nephrotic syndrome is often manifesting in progression of diabetic nephropathy. Therefore, this study was carried out to investigate oxidant and antioxidant status in diabetic nephropathy patients. The blood samples were a...

Earlier Diabetic nephropathy was thought to be a rare complication in Type II Diabetic patients. The incidence and prevalence of nephropathy in Type II Diabetes have been under estimated in the past probably because most patients with nephropathy succumbed to cardiovascular disease, even before nephropathy could manifest clinically. The current study was done to screen Type II diabetic patients...

Mogensen1 made the unique observation that lowering blood pressure in patients with type 1 diabetes and diabetic nephropathy reduced the rate of loss in kidney function. In that study of five insulin-dependent proteinuric men with long-standing diabetes, blood pressure was lowered with combinations of furosemide, prazosin, hydralazine, and -blockers. This observation presaged what has become a ...

Nearly one-half of persons with chronic kidney disease have diabetes mellitus. Diabetes accounted for 44 percent of new cases of kidney failure in 2008. Diabetic nephropathy, also called diabetic kidney disease, is associated with significant macrovascular risk, and is the leading cause of kidney failure in the United States. Diabetic nephropathy usually manifests after 10 years' duration of ty...

Objective. Diabetic nephropathy is a life-threatening complication in patients with long-standing diabetes. Hemodynamic, inflammatory, and metabolic factors are considered as developmental factors for diabetic nephropathy. In this study, we evaluated whether pharmacological interventions with salicylate, compared to pyridoxamine, could prevent diabetic nephropathy in mice. Methods. Male mice ov...