Although diabetogenic and insulin-like activities are intrinsic properties of the growth hormone (GH) molecule, it has been frequently suggested that the hormone must be proteolytically processed for these activities to be expressed. If this is correct, then derivatives of GH having resistance to appropriate proteolytic attack might not have diabetogenic and/or insulin-like activity. The purpos...

Class I and II major histocompatibility complex (MHC) probes can be used to subdivide diabetes-prone BB rats and their BBN control strain, coderived from the same outbred colony by selection against diabetes. Class II probes (A-alpha in particular) distinguish four restriction fragment length polymorphisms (RFLP), termed 1a, 1b, 2a, and 2b, in the BBN population, only one of which (2a) is found...

I. Bovine diabetogenic peptide, growth hormone, and prolactin were compared with respect to their effects on tissue glycogen, liver fat, and liver water in fasting rats. 2. Bovine diabetogenic peptide increases liver size, liver glycogen, liver water, and total liver lipids. 3. Bovine diabetogenic peptide, in contrast to growth hormone and prolactin, does not increase muscle glycogen levels. IN...

1. Four diabetogenic ureides were examined for their power to inhibit alkaline phosphatase and were all highly active. Of ten related compounds examined, two were poor inhibitors of phosphatase although not diabetogenic and non-inhibiting for phosphatase. The anti-phosphatase activity seems to reside in a free 5-hydroxyl group. 2. This action on phosphatase has been demonstrated in the presence...

Diabetogenic T-cells can be detected in pre-diabetic nonobese diabetic (NOD) mice after transfer in NOD-SCID recipients. Here we demonstrate that 6-week-old pre-diabetic NOD mice, >2 months before disease onset, already harbor pathogenic T-cells in equal numbers to overtly diabetic animals. The delay in diabetes appearance is explained by the presence of regulatory CD4+ CD25+ T-cells that contr...

A young woman given a renal allograft for polycystic kidney disease developed insulin dependent diabetes mellitus 25 days after transplantation. There was no family history of diabetes, plasma glucose concentrations had been normal at presentation and on five subsequent occasions, and at no time were islet cell antibodies detectable. Plasma C peptide concentrations, however, were greatly suppre...