Drug induced liver injury (DILI) is a potentially serious adverse reaction in a few susceptible individuals under therapy by various drugs. Health care professionals facing DILI are confronted with a wealth of drug-unrelated liver diseases with high incidence and prevalence rates, which can confound the DILI diagnosis. Searching for alternative causes is a key element of RUCAM (Roussel Uclaf Ca...

37 One of the major challenges in cardiovascular disease is the identification of reliable clinical 38 biomarkers which can be measured routinely in plasma. MicroRNAs were recently 39 discovered to circulate in the bloodstream in a remarkably stable form. Because of their 40 stability and often tissueand disease-specific expression, and the possibility to measure 41 them with high sensitivity a...

Alzheimer’s disease is a chronic brain degenerative condition arising from increasing human aging population stemming high costs in the health system. Since post-mortem brain biopsy is regarded as the definitive diagnosis of AD, developing a non-invasive approach is highly valued. Current cutting-edge medical devices, liposomal and nanoparticle-drug delivery systems as well cerebrospinal fluid ...

In seeking to find diagnostic biomarkers in proteomic spectra, two significant problems arise. First, not only is there noise in the measured intensity at each m/z value, but there is also noise in the measured m/z value itself. Second, the potential for overfitting is severe: it is easy to find features in the spectra that accurately discriminate disease states but have no biological meaning. ...

BACKGROUND Salmonella Typhi and Salmonella Paratyphi A are the agents of enteric (typhoid) fever; both can establish chronic carriage in the gallbladder. Chronic Salmonella carriers are typically asymptomatic, intermittently shedding bacteria in the feces, and contributing to disease transmission. Detecting chronic carriers is of public health relevance in areas where enteric fever is endemic, ...

This study aimed to determine whether the vascular endothelial growth factor (VEGF) family members soluble VEGF receptor 1 (also called soluble fms-like tyrosine kinase 1 (sFlt-1)) and placental growth factor (PlGF) could be used as biomarkers for pulmonary hypertension (PH). Consecutive patients undergoing right heart catheterisation were enrolled (those with mean pulmonary arterial pressure ≥...

Nonalcoholic fatty liver disease is a common medical condition worldwide and its prevalence has increased notably in the past few years due to the increases in prevalence of obesity and metabolic syndrome. However, diagnosis of this disease is still a matter of debate because of disease variations and pathophysiologic alterations. Specific single markers have gained considerable attention recen...