Prognosis of melanoma patients with metastatic disease is very poor. For example, over 95% of melanoma patients with three or more sites of metastatic disease die within 1 year. Treatment failure usually occurs because the drugs used for the treatment of these patients have a low capacity to kill melanoma cells selectively. By using human UACC-62 melanoma cells and human VH-10 skin non-malignan...

OBJECTIVES We sought to determine whether improving coupling between glucose oxidation and glycolysis by stimulating glucose oxidation during reperfusion enhances postischemic recovery of hypertrophied hearts. BACKGROUND Low rates of glucose oxidation and high glycolytic rates are associated with greater postischemic dysfunction of hypertrophied as compared with nonhypertrophied hearts. MET...

Although diabetic cardiomyopathy is widely recognized, there are no specific treatments available. Altered myocardial substrate selection has emerged as a candidate mechanism behind the development of cardiac dysfunction in diabetes. As pyruvate dehydrogenase (PDH) activity appears central to the balance of substrate use, we aimed to investigate the relationship between PDH flux and myocardial ...

Though anti-cancer drugs have been in use since 1971, many still have a fairly low success rate in treating cancer. Since recent studies have linked tumor development to mitochondrial modifications, reversing these changes could reduce tumor size. Cancerous cells suppress their mitochondrial activities and use glycolysis rather than oxidative phosphorylation to synthesize ATP. This process is k...

And the same "case series" observations can be spun off, not later or through "data dredging," but at the same time, to create new hypotheses subject to subsequent data collection. And as new hypotheses are generated, the research consortium is in a position to collect the relevant data with few of the usual delays in forming a research team. By contrast, should the authors' proposals for resea...