One of the phenoxy herbicides, 2-methyl-4-chlorophenoxyacetic acid (MCPA) was soaked with pellet dissolved by corn oil and given to ICR male mice for 18 months at levels of 40, 200, 1,000 and 5,000 ppm (about 3.9, 19.0, 95.6 and 566.4 mg/kg/day, respectively). The animals were then placed on a control diet for 12 months. Treatment with 5,000 ppm of MCPA resulted in a significantly decreased sur...

this study was conducted in the research field of iranian research institute of plant protection in karaj as strip split plots with three replications. the first factor: tillage and no-tillage, and the second factor: herbicide: glyphosate 6 l/ha, 2,4-d + mcpa 2l/ha, glyphosate + 2,4-d + mcpa (6 + 2 l/ha), glyphosate 3 l/ha, 2,4-d + mcpa 1 l/ha, glyphosate + 2,4-d + mcpa (3 + 1 l/ha), and contro...

Kobal S., M. V. Budihna: Toxicity of Herbicides 2,4-D and MCPA for Rats and Rabbits. Acta Vet. Brno 1999, 68: 281-290. A subacute toxicity test using 2,4-dichlorophenoxyacetic acid (2,4-D, 10 mg.kg-1 and 100 mg.kg-1) and 4-chloro-2-methylphenoxyacetic acid (MCPA, 15 mg.kg-1 and 150 mg.kg-1) was carried out on Wistar rats (n = 60) and New Zealand White rabbits (n = 30) of both sexes. The lower d...

A population pharmacokinetic model is proposed for estimation of the brain distribution clearance of synthetic A1 receptor agonists in vivo. Rats with permanent venous and arterial cannulas in combination with a microdialysis probe in the striatum received intravenous infusions of 8-methylamino-N6-cyclopentyladenosine (MCPA) and 2'-deoxyribose-N6-cyclopentyladenosine (2'-dCPA) (10 mg kg(-1)). T...

BACKGROUND Increased intake of probiotic dietary fibre reduces colonic cancer risk. Modified citrus pectin (MCP) requires optimal bioactivity to inhibit galectin-3 (GAL-3) and vascular endothelial growth factor (VEGF). This study evaluated the preventative effect of modified pectin alginate (MCPA) probiotic microbeads on azoxymethane (AOM)-induced colonic carcinogenesis in Balb/c mice. MATERI...

The biological efficacy of herbicides MCPA+tribenuron-methyl (code name: MT-565 SG) and diflufenican+chlorotoluron (Legato Pro 425 SC) was estimated in eighteen field experiments on winter cereals Poland Germany to control broadleaf weeds. Postemergence application tribenuron-methyl combination with MCPA, applied at the 3-leaf stage 3 tillers detectable autumn cereals, resulted majority weed sp...

Future cancer immunotherapies will combine multiple treatments to improve immune responses to cancer through synergistic, multi-modal mechanisms. In a Phase I clinical trial, we found that the immune response to a peptide vaccine targeting survivin, DPX-Survivac, by ovarian cancer patients can be improved by combination therapy with metronomic cyclophosphamide (mCPA). Pre-clinical studies in mi...