Here we report a novel method for the manipulation and concentration of Aβ amyloid fibrils, implicated in Alzheimer's disease, using DC insulating gradient dielectrophoresis (DC-iGDEP). Fibril enrichment was found to be ∼400%. Simulations suggest that capture of the full range of amyloid protein aggregates is possible with optimized device design.

Nano Letters is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Letter Rapid and Reproducible Fabrication of Carbon Nanotube AFM Probes by Dielectrophoresis Jie Tang, Guang Yang, Qi Zhang, Ahmet Parhat, Ben Maynor, Jie Liu, Lu-Chang Qin, and Otto Zhou Nano Lett., 2005, 5 (1), 11-14 • DOI: 10.1021/nl048803y Downloaded from http://pubs.acs.org on Janua...

The ability to manipulate biological cells and micrometer-scale particles plays an important role in many biological and colloidal science applications. However, conventional manipulation techniques, such as optical tweezers, electrokinetic forces (electrophoresis, dielectrophoresis (DEP), and traveling-wave dielectrophoresis), magnetic tweezers, acoustic traps, and hydrodynamic flows, cannot a...

The principle and recent experimental results of optoelectronic tweezers (OET) will be presented. Based on lightinduced dielectrophoresis, OET can trap and sort colloidal particles, biological cells, nanowires and nanoparticles using a digital light projector. ©2009 Optical Society of America OCIS codes: (170.4520) Optical confinement and manipulation; (350.4855) Optical tweezers or optical man...

The transport phenomema electrokinesis and dielectrophoresis are studied theoretically, experimentally, and computationally. Novel electrokinesis-based microfluidic devices are synthesized to solve practical engineering problems including turning and injecting analyte bands. The novel experimental methodology used to validate the theory and computational software tools is described and presente...

We demonstrate the use of phospholipid vesicle electroformation techniques [1] to develop a new class of metrology tools for systems leveraging dielectrophoresis (DEP) to manipulate, pattern, and sort micron-scale particles. These cell-sized phospholipid vesicles, commonly called giant unilamellar vesicles or GUVs, possess specifically engineered electrical properties and thus exhibit identifia...

References 1. Pethig R. Application of A.C. electrical fields to the manipulation and characterisation of cells. In: Karube I, ed. Automation in biotechnology. Amsterdam: Elsevier, 1991:159–85. 2. Pohl HA. Dielectrophoresis. Cambridge: Cambridge University Press, 1978: 579. 3. Pethig R. Dielectrophoresis. Using inhomogeneous AC electrical fields to separate and manipulate cells. Crit Rev Biotec...