Abstract Cancer‐related fatigue (CRF) and stress are common symptoms in cancer patients represent early side effects of treatment which affect the life quality patients. CRF may partly depend on disruption circadian rhythm. Locomotor activity corticosterone rhythms two important outputs can be used to analyze possible function during development treatment. The present study analyzes relationshi...

Dimethylnitrosamine and diethylnitrosamine, two potent carcinogens, are nonmutagenic when tested directly in microorganisms. Likewise l-naphthylamine and 2-naphthylamine are also nonmutagenic but the N-hydroxy derivatives are mutagenic in microorganisms. Apparently these compounds require metabolism to breakdown products which are then the proximately active agents, and microorganisms lack the ...

The levels of seven enzymes involved in the metabolism of 1-carbon compounds and their precursors were investigated in the cytoplasmic fractions of the livers of rats receiving the hepatocarcinogens diethylnitrosamine, 2-acetylaminofluorene, and 7V,./V-dimethyl-4-aminoazobenzene for 1 to 5 weeks. The enzymes studied included serine hydroxymethylase, dihydrofolate reducÃ-ase (H2-folate reducÃ-as...

Background: Liver diseases including chronic hepatitis, steatosis, fibrosis, cirrhosis and liver cancer are now a public health problem. In 2002, accounted for 27.63% of hepatobiliary in Burkina Faso. Africa more particularly Faso, the majority population (about 80%) uses medicinal plants their primary care. Calotropis procera (Ait.) R.Br (Apocynaceae) is plant used Faso treatment problems. Thi...

The CCAAT/enhancer binding protein alpha (C/EBPalpha) is vital for establishing normal hepatic energy homeostasis and moderating hepatocellular growth. CEBPA loss-of-function mutations identified in acute myeloid leukemia patients support a tumor suppressor role for C/EBPalpha. Recent work showed reductions of C/EBPalpha levels in human hepatocellular carcinoma with the reductions correlating t...

Transfer of the herpes simplex virus-thymidine kinase (HSV-tk) gene followed by the administration of ganciclovir (GCV) into hepatocellular carcinoma (HCC)-derived cell lines either in vitro or transplanted into nude mice has been shown to provide a potential strategy for HSV-tk-based gene therapy of HCC. We report herein an analysis of the antitumoral efficacy of two recombinant adenoviruses (...

Chromatographic separation of native DNA from DNA containing single-stranded regions has been used to determine the relative concentrations of structural intermediates generated during chemically induced DNA repair. Single doses of each of ten compounds were administered to rats. After periods ranging from 90 min to 13 days, hepatic DNA was isolated and analyzed by stepwise elution from benzoyl...

The glycosyltransferase termed GlcNAc-TIII is dedicated to the trans fer of a single W-acetylglucosamine (GlcNAc) residue (the bisecting GlcNAc), to a subset of W-glycans in glycoproteins. The addition of this GlcNAc is differentially regulated during development and is induced in certain cancers, particularly in hepatic tumorigenesis. To investigate a functional role for the bisecting GlcNAc i...