Plasma myocardial, and skeletal muscle digoxin concentrations were measured in 32 patients undergoing cardiopulmonary bypass who were on long-term treatment with digoxin. The patients were divided into 4 groups according to the daily digoxin dose and the interval between discontinuation of the drug and operation. Before bypass, the mean digoxin concentrations were 1.58 nmol/l (1.24 ng/ml) in pl...

Digoxin was developed as a novel medication for the treatment of heart failure and atrial fibrillation (AF) 200 years ago. This investigation began with PubMed Google Scholar search various papers using terms digoxin safety efficacy, in failure, fibrillation. should be administered at dose 0.5–0.7 ng/mL individuals reduced ejection fraction. to decrease hospital readmissions, although SDC, crea...

introduction: pneumonectomy is the standard treatment of lung cancer, even though patients should undergo several evaluations before surgery; deterioration of cardiopulmonary function after pulmonary resection is inevitable. we have evaluated the effects of digoxin on the improvement of right ventricular function and prevention of probable complications after lung resection surgery. materials a...

To study the relationship of the serum digoxin concentration to the digoxin effect on monovalent cation transport during the quinidine-digoxin interaction, we used radiolabeled rubidium to measure monovalent cation active transport in myocardial biopsy samples from dogs. In a preliminary study, we showed that quinidine did not affect rubidium uptake by myocardial samples from intact dogs. Then,...

Controversy persists regarding the role of tubular reabsorption and secretion in the renal handling of digoxin. To determine the effect of reduction in renal perfusion pressure and blood flow on digoxin clearance during acute and chronic digoxin administration, renal clearances of digoxin and inulin were measured in pentobarbital-anesthetized dogs before and after repeated unilateral renal arte...

CONTEXT Ashwagandha, a popular Ayurvedic medicine, is now available in the United States. Alkaloids found in this herb have structural similarity with digoxin. OBJECTIVE To study potential interference of Ashwagandha with serum digoxin measurement by immunoassays. Potential interference was also investigated with immunoassays for 11 other commonly monitored drugs. In addition, interaction of ...

An investigation into the relations between the daily dose of digoxin, drug regimen, serum digoxin concentration, and creatinine and digoxin clearance was carried out in a group of elderly ambulant patients in domiciliary practice. Moderate to severe impairment of renal function was found both in patients taking digoxin and in elderly control subjects. Plasma digoxin levels were not related to ...

P-glycoprotein (P-gp) is an ATP-dependent efflux membrane transporter involved in many drug pharmacokinetics in humans. Decreasing its expression could enhance the bioavailability of substrates as digoxin. We have recently found that human recombinant interleukin-2 (rIL2) in vivo decreases P-gp expression in intestine and brain of mice and modifies oral digoxin pharmacokinetics. The aim of the ...

was found between digoxin dosage and plasma digoxin concentration. Patients who did not develop symptoms of digitalis intoxication until at high doses showed a slower increase ofplasma levels. At the first appearance of toxic symptoms 'steady state' values of about 6 ng digoxin/ml werefound. Excluding one divergent patient, a close inverse correlation wasfound between plasma digoxin concentrati...

The study was a prospective observational trial carried out to assess the clarithromycin-digoxin interaction in elderly patients chronically taking digoxin. Digoxin concentrations were determined before and after concomitant treatment with clarithromycin. A Bayesian approach was used to calculate digoxin pharmacokinetics. In the seven patients who were studied there was a significant increase i...