Dengue virus (DENV), the causative agent of dengue disease, is among the most important mosquito-borne pathogens worldwide. DENV is composed of four closely related serotypes and belongs to the Flaviviridae family alongside other important arthropod-borne viral pathogens such as Zika virus (ZIKV), West Nile virus (WNV) and Yellow Fever virus (YFV). After infection, the antibody response is most...

We have undertaken a series of experiments to examine the behavior of individual components of cell membranes. Here we report an initial stage of these experiments, in which the properties of a chemically simple lipid mixture are carefully mapped onto a phase diagram. Four different experimental methods were used to establish the phase behavior of the 3-component mixture DSPC/DOPC/chol: (1) con...

In this experiment, we study the antibunching phenomenon in the photons produced by single emitter quantum dots using a Hanbury Brown-Twiss setup. We also measure the single emitter fluorescence lifetime using DiI dye molecules.

Hypercholesterolemic rabbit beta-VLDL and human LDL are both internalized by mouse peritoneal macrophages by receptor-mediated endocytosis. However, only beta-VLDL (which binds to the cells with a much higher affinity than LDL) markedly stimulates acyl-CoA/cholesterol acyl transferase (ACAT) and induces foam cell formation in these cells. As an initial step to test whether the two lipoproteins ...

Background Previous studies have shown that the minor allele (C allele) for melanocortin 4 receptor (MC4R) rs17782313, may be associated with incidence of obesity and risk cardiovascular diseases (CVDs). Moreover, inflammation caused by diet has been to have, potentially, unfavorable effects on CVD risk. This study used a linear regression model investigate interactions between dietary inflamma...

A colite ulcerativa (CU) e a doença de Crohn (DC) representam as doenças inflamatórias intestinais (DII), um grupo condições que possuem sintomas semelhantes levam à inflamação do trato digestivo. CU se caracteriza por uma limitada ao intestino grosso, caráter crônico, alternando entre períodos remissões recidivas. Já na DC, pode acometer todo o gastrointestinal, apresentando forma crônica, pro...

The present study analyzes and assesses the robustness of monitoring effectiveness institutional investment against information asymmetry prevailing in market, especially asymmetric Domestic Institutional Investment (DII) vis-à-vis Foreign (FII). Drawing from a sample listed non-financial firms with 20% or more, this tests relationship between earnings management ownership controlling for known...

The glomerular layer of the mammalian olfactory bulb (OB) forms odorant receptor (OR) maps. Each OR map is structurally and functionally compartmentalized into zones (dorsal and ventral) and domains (DI and DII in the dorsal zone). We previously reported that glomeruli with similar molecular receptive range properties formed molecular feature clusters at stereotypical positions in the rat OB. H...