The purpose of this study was to test the hypothesis that endothelium-dependent dilation (flow-induced dilation and ACh-induced dilation) in rat soleus muscle arterioles is impaired by hindlimb unweighting (HLU). Male Sprague-Dawley rats (approximately 300 g) were exposed to HLU or weight-bearing control (Con) conditions for 14 days. Soleus first-order (1A) and second-order (2A) arterioles were...

BACKGROUND The optimal timing of epidural analgesia has been a controversial issue, and how early women can benefit from epidural analgesia is still debated. The objective of this trial was to test the hypothesis that patient-controlled epidural analgesia given at cervical dilation of 1.0 cm or more does not increase the risk of prolonged labor or Cesarean delivery. METHODS After institutiona...

BACKGROUND AND OBJECTIVE Increased air pollutants correlate with increased incidence of cardiovascular disease potentially due to vascular dysfunction. We have reported that acute diesel engine exhaust (DE) exposure enhances vasoconstriction and diminishes acetylcholine (ACh)-induced dilation in coronary arteries in a nitric oxide synthase (NOS)-dependent manner. We hypothesize that acute DE in...

Objective: This study aims to evaluate the safety and clinical efficacy of warfarin anticoagulation after small balloon pre-dilation for treating Budd-Chiari syndrome (BCS) complicated with inferior vena cava (IVC) thrombosis. Methods: This prospective study analyzed the consecutive clinical data of 53 patients with BCS complicated with IVC thrombosis, who were admitted in our hospital from Jan...

Glutamine has been shown to influence endothelial-dependent relaxation and nitric oxide production in vitro, possibly by limiting arginine availability, but its effects in vivo have not been well studied. Hyperammonemia is a pathophysiological condition in which glutamine is elevated and contributes to depressed CO(2) reactivity of cerebral arterioles. We tested the hypothesis that acute hypera...

PURPOSE To determine the mydriatic regimen that provides optimal dilation of the pupil with minimal systemic side effects for screening of retinopathy of prematurity. METHODS This cross-sectional, randomized, double-masked clinical trial compared cyclopentolate 1% + phenylephrine 2.5%, tropicamide 1% + phenylephrine 2.5%, and a prepared combination of cyclopentolate 0.2% with phenylephrine 1%...

Background: A number of conditions demands first trimester abortions including medical and social causes. This study was mainly undertaken in order to compare the oral misoprostol with intramuscular carboprost for cervical ripening suction evacuation termination pregnancy up 12 weeks gestation. Material methods: randomized controlled trial determine safety efficacy over ripening. total 120 preg...

background one of the strategies for a good outcome and pain free childbearing is to design the delivery room. objectives the aim of this study was to evaluate the effects of snoezelen room on childbearing outcome such as pain intensity, duration of labor, and perinea status in nulliparous women. patients and methods this study was a randomized controlled clinical trial consists of 100 childbea...

critical pulmonary valve stenosis (cpvs) and atrial septal defect (asd) is an uncommon form of congenital heart disease. concurrent transcatheter pulmonary valvuplasty and closure of secundum atrial septal defect appears to be an interesting alternative to surgical correction. we present the simultaneous balloon valvuloplasty of critical pulmonary stenosis (ps) with supra systemic right ventric...