J.M. Campistol, Renal Transplant Unit, Hospital Clinic i Provincial, C. Villarroel 170, E-08036 Barcelona (Spain) Dear Sir, Recently, ketoconazole has been proposed to associate with ciclosporin immunosuppressive therapy because of the inhibitory effect on ciclosporin liver metabolism by inhibition P-450 microsomal enzymes, and the financial consequences of this pharmacological interaction [1]....

In this study, the systemic and coronary hemodynamic changes associated with the administration of diltiazem, a recent calcium antagonist, were evaluated in three different situations as follows: following a 200 microgram/kg intravenous bolus of the drug in 12 open-chest anesthetized dogs; following two successive intravenous infusions of diltiazem (15 microgram/kg/min and 30 microgram/kg/min),...

Calcium channel blockers depress atrioventricular (AV) nodal properties in vivo in a frequency-dependent manner, suggesting that selective drug action during supraventricular arrhythmias may result from use-dependent properties. The present study was designed to examine whether or not the rate-dependent actions of diltiazem account for its therapeutic effects during atrial fibrillation. The det...

The effects of intravenous infusion of diltiazem on regional blood flow (radioactive microspheres), hemodynamics, and maximum rate of oxygen consumption were evaluated in conscious rats with congestive heart failure caused by large myocardial infarction (n = 10, infarct size 41.8% of left ventricle) and compared with data obtained from rats subjected to sham surgical procedures (n = 9). In both...

A new coated-wire electrode based on PVC membrane plasticized with dioctyl phthalate (DOP) and containing the diltiazem-tetraiodido bismuthate (III) ion association coated a silver wire was constructed used for potentiometric determination of diltiazem hydrochloride. The performance characterized optimized according to following experimental criteria: composition, soaking time, working pH range...

The purpose of this study was to evaluate a contribution of polymorphic cytochrome P450 (CYP) 3A5 to the oxidation of diltiazem, midazolam and testosterone by liver microsomes from Japanese subjects. Twenty-seven liver samples were classified into three groups according to the CYP3A5 genotypes; CYP3A5(*)1/(*)1 (n=3), (*)1/(*)3 (n=12) and (*)3/(*)3 (n=12). The results of genotyping and immunoche...

Calcium influx blockers reportedly suppress ventricular arrhythmias during acute ischemia. We therefore studied the effects of diltiazem and reduced serum ionized calcium on ventricular fibrillation (VF) in a reversible ligation model. VF was produced at 15-minute intervals by simultaneous occlusion of the left anterior descending and circumflex arteries of 31 dogs. Time from coronary occlusion...

OBJECTIVE To compare the symptomatic relief, healing and side-effects of topical diltiazem (DTZ) and glyceryl trinitrate in the treatment of chronic anal fissure. STUDY DESIGN Randomized controlled trial. PLACE AND DURATION OF STUDY The Surgical Outpatient Department of Civil Hospital, Karachi, from March 2006 to February 2007. METHODOLOGY Patients with chronic anal fissure were included ...