Spathodea campanulata Beauv. is an important plant widely used in traditional medicine for the treatment of hepatic disease. In present study, we evaluate phytochemical composition and hepatoprotective potential effect stem root bark extracts companulata on dimethylnitrosamine (DEN) induced impairment albino rats. Phytochemical compositions were analyzed using standard protocols. Forty-five mal...

The toxic and carcinogenic actions of four methylnitrosamine or -amide compounds, given as a single intraperitoneal injection to newborn and adult inbred Swiss mice, were examined. Toxicity was approximately directly proportional to the stability of the three compounds capable of methylating macromolecules in vitro. Methylnitrosourea induced a high incidence of thymic lymphomas in adults and ne...

While it has been generally accepted that genotoxic carcinogens have no dose threshold for their carcinogenic potential, there is increasing evidence that very low doses in fact are incapable of inducing tumours or preneoplastic lesions. Thus not only so-called epigenetic 'non-genotoxic' compounds like phenobarbital and benzene hexachloride, but also unequivocally genotoxic carcinogens like the...

Diabetes was induced in rats with Streptozotocin and alloxan and the tumorogenic effects of these two compounds were compared. One hundred thirty Lewis and SpragueDawley rats survived the induction of diabetes with Strepto zotocin. Fifty-six of these animals were sacrificed within 8 months of Streptozotocin administration and three were found to have renal tumors. Twenty-four of 74 (30.8%) Stre...