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OBJECTIVES Complications such as ascites during the pathogenesis of hepatic fibrosis and cirrhosis may lead to several abnormalities in mineral metabolism. In the present investigation, we have monitored serum and liver concentrations of calcium, magnesium, sodium and potassium during experimentally induced hepatic fibrosis in rats. DESIGN AND METHODS The liver injury was induced by intraperi...

In the article entitled "The in vitro Induction of an Increase in Cell Multiplication and Cellular Life Span by the Water-Soluble Carcinogen Dimethylnitrosamine," by Eliezer Huberman, Samuel Salzberg, and Leo Sachs, which appeared in the January 1968 issue of these PROCEEDINGS (vol. 59, pp. 77-82), the order of some of the sentences in the second paragraph of Results was reversed. The paragraph...

The rat is a frequently used experimental model in studies involving human disease. We review several methods of inducing hepatic fibrosis and cirrhosis in rats. These include induction by hepatotoxins and hepatocarcinogens such as carbon tetrachloride, dimethylnitrosamine, thioacetamide and furan; the hepatoxin-cum-nutrient, alcohol; a high fat-low choline-low protein diet; immunologic agents ...