BACKGROUND Tamoxifen's cost-benefit ratio for breast ductal intraepithelial neoplasia (DIN) is unclear. Since low-dose tamoxifen showed a favorable modulation of breast cancer biomarkers in phase II trials, a monoinstitutional cohort of women with DIN treated with low-dose tamoxifen or no systemic treatment was analyzed. PATIENTS AND METHODS A total of 309 patients with DIN received low-dose ...

This paper will enumerate the last days of rule Sultanate Kashmir, which was originally founded in very tough conditions by a Swati Muslim commander, Shah Mir, later known as Sultan Shams din and counted to be second king first Sultan, who, according all estimates, considered most important figure among Lahora nobility. Hindu usually ended with defeat Kota Rani at Inderkot Safapora, 1339 A.D., ...

This article examines the period of internecine struggle in Khorezm state after death Shah Abu’l-Fath Il-Arslan (1156–1172) between his sons — Sultan Mahmud and ‘Ala’ ad-Din Tekish. Despite fact that this episode from Anushteginid dynasty is relatively well known to scholars, there has not yet been a single special study how war or “Khorezmian sedition” was reflected synchronous Muslim texts 12...

Formulae for the number of branch points of one-dimensional orbifolds defined over a non-archimedean local field and uniformisable by discrete projective linear groups are given. They depend only on the uniformising group. The method of equivariant pasting reveals the possible relative position of the branch points.

Dissolved inorganic nitrogen (DIN) movement from Australian sugarcane farms is believed to be a major cause of crown-of-thorns starfish outbreaks which have reduced the Great Barrier Reef coral cover by ~21% (1985-2012). We develop a daily model of DIN concentration in runoff based on >200 field monitored runoff events. Runoff DIN concentrations were related to nitrogen fertiliser application r...

BACKGROUND Nephropathic cystinosis is a rare inherited metabolic disorder leading to progressive renal failure and extra-renal comorbidity. The prognosis relies on early adherence to cysteamine treatment and symptomatic therapies. Developing nations [DiN] experience many challenges for management of cystinosis. The aim of this study was to assess the management characteristics in DiN compared w...

This article focuses on Mehmet Tahir Münif Paşa’s second ambassadorship to Iran (1896–1897) in the aftermath of Nasir al-Din Shah Qajar’s assassination May 1896. It argues that Shah’s death brought about a turning point Perso-Ottoman diplomatic relations and Sultan Abdülhamid’s decision assign as his representative Tehran was an affirmation new age Ottoman foreign policy. In what follows, will ...