Geeldikkop was induced in a sheep by oral administration of crude saponins from Tribulus terrestris. Centrifugation of the bile from this sheep gave a pale green sediment of crystalloid material which was insoluble in common organic solvents, but soluble in acetic acid. Analysis of the crystalloid material by 1H and 13C NMR, EDXA, TLC, LSIMS, and by acidic hydrolysis followed by TLC and GC-MS, ...

Ranti Hitam known as local name of ( Solanum blumei Nees ex Blume) found in the Dairi, Sumatera Utara, Indonesia. It is used by community traditional medicine which contains various phytochemical constituent steroidal alkaloids β2-solanin, diosgenin, flavonoids, saponins and tannins. The purpose study was to investigate anticholesterol activity ethanol extract vivo insilico methods. A number 15...

Studying the biotransformation of natural products by intestinal microflora is an important approach to understanding how and why some medicines-particularly natural medicines-work. In many cases, the active components are generated by metabolic activation. This is critical for drug research and development. As a means to explore the therapeutic mechanism of Dioscorea nipponica (DN), a medicina...

Much attention has been paid to diosgenin saponins because of their various bioactivities, whereas their gelation ability has never been reported. We synthesized some new saponins with pentose directly connected to diosgenin in a shorter procedure, which neither removed the acetyl group of the anomeric hydroxyl group selectively nor activated it and led to a higher yield, compared with the comm...

Abstract Background Diosgenin is an isospirostane derivative, which a steroidal sapogenin and the product of acids or enzymes hydrolysis process dioscin protodioscin. Galactomannans are heteropolysaccharides composed D-mannose D-galactose, major sources locust bean, guar, tara fenugreek. Methods Literature survey was accomplished using multiple databases including PubMed, Science Direct, ISI we...

Abstract In a mouse model of Graves’ disease (GD), diosgenin has been shown to have therapeutic effect on GD by alleviating goitre. However, research the autoimmune thyroiditis (AIT) is lacking. this study, transcriptomics was used comprehensively analyse protective against AIT in rats and possible mechanism. The results showed that diosgenin-intervention group, compared expression serum triiod...

In vitro the production of natural diosgenin from callus culture became an alternative biotechnological approach to production. This study describes effect plant growth regulators (PGRs) on induction and using different elicitors in induce (Diosgenin) parts Balanites Aegyptiacae extract cell lines. Root, stem, leaves calture B. aegyptiacae, were raised Murashing skoog Medium (MS) supplemented w...