Anti-N-methyl-d-aspartate (Anti-NMDA) receptor encephalitis is an acute autoimmune neurological disorder. The cause of this disease is often unknown, and previous studies revealed that it might be caused by a virus, vaccine or tumor. It occurs more often in females than in males. Several cases were reported to be related to vaccination such as the H1N1 vaccine and tetanus/diphtheria/pertussis a...

OBJECTIVE To evaluate the safety of infant immunization with acellular pertussis vaccines in the United States. BACKGROUND The US Food and Drug Administration approved the first acellular pertussis vaccine for use in infants in the United States on July 31, 1996. OUTCOME MEASURES Adverse events in the United States after infant immunization with pertussis-containing vaccines, representing t...

Administration of diphtheria and tetanus toxoids and pertussis vaccine adsorbed (DTP vaccine) or endotoxin (LPS) resulted in marked alterations in hepatic drug-metabolizing enzymes in endotoxin-responsive (R) and non-endotoxin-responsive (NR) mice. A single human dose (0.5 ml) of DTP vaccine increased hexobarbital-induced sleep times to 1.6- to 1.8-fold above those of controls in both strains o...

OBJECTIVE In 2010, California experienced the highest number of pertussis cases in >60 years, with >9000 cases, 809 hospitalizations, and 10 deaths. This report provides a descriptive epidemiologic analysis of this epidemic and describes public health mitigation strategies that were used, including expanded pertussis vaccine recommendations. STUDY DESIGN Clinical and demographic information w...

where C(x) = 1 − 3x + x 2 /2 + x 3 /30. Note that C (x) is positive for x > 3 and C(9/2) = 53/80. Hence C(x) is positive for x > 9/2 and the bounds are established. We can now write F (z) > z 2 0 e −zt dt + z ∞ 2 2t 2 e −(z+1)t dt, and thus F (z) > 1 + e −2z−2 (w(z) − e 2), where w(z) = 8 − 4 (z + 1) 2 − 4 (z + 1) 3. Note that w(z) increases from 200/27 at z = 2 to 8 at z = ∞. Since 200/27 > e ...

In pneumococcal conjugate vaccines (PCVs), polysaccharide antigens are often conjugated to protein carriers related to other common vaccines. It is therefore important to test PCV interaction with other pediatric vaccines when administered simultaneously. We assessed the immune response to an 11-valent PCV conjugated to diphtheria and tetanus carriers (PncD/T11), administered concomitantly, but...

We evaluated the reactogenicity and immunogenicity of a booster dose of diphtheria-tetanus vaccine administered at the age of school-entry, comparing a low-dose vaccine (dT) to the standard paediatric dose (DT). Participants were randomly assigned to receive one of the two vaccines; the study was evaluator-blinded. The frequency of side-reactions was similar when comparing the two groups, excep...

BACKGROUND Thimerosal is an ethylmercury-containing compound (49.6% mercury by weight) used as at the preservative level in vaccines (0.005% to 0.01%). METHODS Statistical modeling in a meta-analysis epidemiological assessment of the Vaccine Adverse Event Reporting System (VAERS) for neurodevelopment disorders (NDs) reported following Diphtheria-Tetanus-whole-cell-Pertussis (DTP) vaccines in ...

OBJECTIVE To describe a complication of oral vaccination with live, attenuated poliomyelitis virus in a child infected with HIV. DESIGN Case report. SETTING Teaching hospital in Harare, Zimbabwe. SUBJECTS A boy of 41/2 years and his mother. MAIN OUTCOME MEASURES Results of clinical and laboratory investigations. RESULTS Two weeks after receiving the second dose of oral poliomyelitis v...