John B RobbinsRachel SchneersonBirger TrollforsHiroko SatoYuji SatoRino RappuoliJerry M Keith
Replacement of cellular with acellular pertussis (aP) vaccines has considerably reduced the systemic reactions observed with diphtheria-tetanus toxoids-pertussis vaccine but has not eliminated the extensive swelling (sometimes involving an entire limb) observed after the fifth injection of diphtheria-tetanus toxoids-aP (DTaP) vaccine. This local reaction, which is likely an Arthus hypersensitiv...
:Clinical infectious diseases : an official publication of the Infectious Diseases Society of America2010
Stanley C WeiKathleen TattiKimberly CushingJennifer RosenKristin BrownPamela CassidayThomas ClarkRichard OlansLucia PawloskiMonte MartinMaria Lucia TondellaStacey W Martin
Pertussis is among the most poorly controlled bacterial vaccine-preventable diseases in the United States. In 2006, a tetanus, reduced-dose diphtheria, and acellular pertussis (Tdap) booster was recommended for adolescents and adults. Tdap vaccines were licensed on the basis of antibody response without vaccine effectiveness data.
From 30 September 2007 through 19 December ...
Prasad S. KulkarniSidram K. RautSanjay P. DhorjePrajakt J. BardeGirish KoliSuresh S. Jadhav
Rise of diphtheria cases in adults is a cause of concern worldwide. Pertussis is also now affecting adults. We assessed serum levels of tetanus, diphtheria and pertussis antibodies in 62 adults in Pune, India, who had missed their primary immunization. All adults were then given three doses of tetanus-diphtheria (Td) vaccine at 0, 1, and 6 months. All adults were immune to tetanus but 78% had l...
We studied the effect on neurodevelopment of infants who are exposed to thimerosal in tetanus-diphtheria (Td) vaccines during pregnancy.
We compared Gesell Developmental Schedules (GDS) of exclusive breastfed infants at 6 months born to mothers who received Td (1 to 3 doses) against those who were born to mothers who did not take such vaccines.
Compared with the group of...
:Clinical infectious diseases : an official publication of the Infectious Diseases Society of America2013
Hung Fu TsengLina S SyLei QianS Michael MarcyLisa A JacksonJason GlanzJim NordinRoger BaxterAllison NalewayJames DonahueEric WeintraubSteven J Jacobsen
Published data on the safety of tetanus-diphtheria-acellular pertussis vaccine (Tdap) in persons aged ≥65 years are limited. This study aims to examine a large cohort of Tdap users ≥65 years for evidence of increased risk of adverse events following vaccination.
A matched cohort study design and a self-controlled case series (SCCS) design were used. The study population was...