The Rat Genome Database (RGD) is the premier resource for genetic, genomic and phenotype data for the laboratory rat, Rattus norvegicus. In addition to organizing biological data from rats, the RGD team focuses on manual curation of gene-disease associations for rat, human and mouse. In this work, we have analyzed disease-associated strains, quantitative trait loci (QTL) and genes from rats. Th...

because of the huge amounts of proteomic data and demand for new methods of laboratory analysis results, proteins collective analysis, in addition to taking less time, biostatistician assist at identification of new patterns in the data set. in this study, rat hippocampus proteome in normal and alzheimer's disease (ad) were analyzed by using proteomic techniques and bioinformatics’ analysis. pr...

introduction: intracerebroventricular (i.c.v.) injection of streptozotocin (stz) to rodents has been reported as an appropriate model for sporadic dementia of alzheimer's type (sdat), characterized by a progressive impairment of memory. however, very little or nothing is known about non-cognitive behavioral effects in the stz model. this study was carried out in order to show the protectiv...

1. Abstract 2. Introduction 2.1. Apoptosis 2.2. Caspases 2.2. Apoptosis and glaucoma 2.3. Caspase substrates in Alzheimer's disease 3. Methods 3.1. Chronic ocular hypertensive rat glaucoma model 3.2. Intraocular pressure (IOP) measurement and analysis 3.3. Optic nerve axon counts 3.4. Immunohistochemistry 3.5. Immunogold electron microscopy 3.6. ELISA 4. Rat model of chronic ocular hypertension...

Rattus norvegicus, the laboratory rat, has been a crucial model for studies of the environmental and genetic factors associated with human diseases for over 150 years. It is the primary model organism for toxicology and pharmacology studies, and has features that make it the model of choice in many complex-disease studies. Since 1999, the Rat Genome Database (RGD; http://rgd.mcw.edu) has been t...

Excess NaCl increases blood pressure in some strains of animals but not others. An 8% NaCl diet did not change renal thiazide receptor (TZR) density in two salt-resistant normotensive rat strains (Wistar-Kyoto and Sprague-Dawley) [Fanestil, D. D., D. A. Vaughn, and P. Blakely. Am. J. Physiol. 273 ( Regulatory Integrative Comp. Physiol.42): R1241-R1245, 1997]. However, the renal response to salt...

The suitability of an animal model for use in studying human diseases relies heavily on the similarities between two species at genetic, epigenetic, and metabolic levels. However, there is a lack consistent data from different models each level to evaluate this suitability. With availability genome sequences many mammalian species, it now possible compare based genomic similarities. Herein, we ...

Background: Alzheimer’s disease (AD) is characterized by progressive neuronal loss in hippocamp. Epidermal neural crest stem cells (EPI-NCSC) can differentiate into neurons, astrocytes and oligodendrocytes. The purpose of this study was to evaluate the effects of transplanting EPI-NCSC into AD rat model. Methods: Two weeks after induction of AD by injection of Amyloid-β 1-40 into CA1 area of ra...