نتایج جستجو برای: disease rat
تعداد نتایج: 1740446 فیلتر نتایج به سال:
Background: Autophagy is a mechanism disassembling the damaged organelles from the cell. This study attempted to examine the expression of several autophagy-related genes in Parkinson’s disease (PD) rat model. Methods: The male Wistar rats were divided into three groups as control, sham, and lesion. In the latter group, the PD rat model was induced by the injection of 6-hydroxydopamine in...
The effects of age and blood pressure on fibronectin expression in the rat heart were studied in the normotensive Wistar and Wistar-Kyoto (WKY) strains and in the spontaneously hypertensive rat (SHR). Fibronectin mRNA expression decreased threefold between 10 and 40 weeks of age in Wistar hearts, with changes of similar magnitude occurring between 6 and 24 weeks in WKY rats. In contrast, no dec...
هدف از تحقیق حاضر بررسی نقش رسپتور های cb1 کانابینوئیدی ناحیه آمیگدال مرکزی در پاداش ناشی از مرفین در موش نر بزرگ آزمایشگاهی نژاد wistar می باشد. نتایج به دست آمده نشان داد که سه روز تزریق زیر جلدی مرفین (2, 4, 6 mg/kg ) می تواند ترجیح مکان شرطی شده وابسته به مقدار را در این حیوانات القاء کند. مرفین هیچ گونه اثری بر فعالیت حرکتی موش شرطی شده در زمان انجام آزمون نداشت. تزریق درون مغزی آگونیست رس...
In the United Kingdom, following the emergence of Seoul hantavirus in pet rat owners in 2012, public health authorities tried to communicate the risk of this zoonotic disease, but had limited success. To explore this lack of engagement with health advice, we conducted in-depth, semi-structured interviews with pet rat owners and analysed them using a grounded theory approach. The findings from t...
The effects of repeated sensory stimulation (electro-acupuncture) and physical exercise (running) on open-field behaviour and on hippocampal concentrations of neuropeptide Y, neurokinin A, substance P, galanin and vasoactive intestinal peptide (VIP)-like immunoreactivities were studied in WKY (wistar-Kyoto) and SHR (spontaneously hypertensive) rats. Significantly higher concentrations of substa...
Showing that an animal is hyperactive is not sufficient for it to be accepted as a model of ADHD. Based on behavioral, genetic, and neurobiological data, the spontaneously hypertensive rat (SHR) obtained from Charles River, Germany, (SHR/NCrl) is at present the best-validated animal model of ADHD. One Wistar Kyoto substrain (WKY/NHsd), obtained from Harlan, UK, is its most appropriate control. ...
Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto ("WKY") rats are frequently employed in experimental studies of hypertension. Although both SHR and WKY rat strains have been presumed to be fully inbred, recent studies have revealed important biologic variability in WKY rats from different commercial sources. Genealogic evidence suggests that, in the United States, breeding s...
Acupuncture for the treatment of Parkinson's disease has a precise clinical outcome. This study investigated the effect of electroacupuncture at Fengfu (GV16) and Taichong (LR3) acupoints in rat models of Parkinson's disease induced by subcutaneous injection of rotenone into rat neck and back. Reverse transcription-PCR demonstrated that brain-derived neurotrophic factor and glial cell line-deri...
اسید آسکوربیک درغلظت های بالاو با انتشارپراکنده در مغز پستانداران وجود دارد . مطالعات قبلی نشان داده است که اسید آسکوربیک درسیستم عصبی مرکزی، می توانند عملکرد حافظه و یادگیری را تحت تاثیر قرار دهد. هدف از تحقیق حاضر، ارزیابی اثرات افزایشی و کاهشی اسیدآسکوربیک در داخل جسم مخطط بر روند یادگیری و حافظه فضایی در موش های صحرایی نر بالغ به وسیله ماز آبی موریس می باشد. در این تحقیق 56 سر موش صحرایی...
objective(s):micrornas (mirnas) are small non-coding rna molecules that regulate gene expression. they have important roles in kidney development, homeostasis and disease, and participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (ckd). in the present study, we elucidated the role of micror...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید