We investigated the involvement of loci on the sex chromosomes in the hypertension of the spontaneously hypertensive rat (SHR) by studying male F, and F2 generation rats derived from reciprocal crosses of SHR with Wistar-Kyoto (WKY) rats (cross 1: WKY female x SHR male; cross 2: SHR femalexWKY male). At 16 weeks of age there was no significant difference in the blood pressures of F, animals der...

Background Traditionally, the plant was used for various diseases, including neuronal disorders. To evaluate neuroprotective activity of Hibiscus vitifolius L. against Colchicine induced Alzheimer’s disease in rat model. Method Neuroprotective carried out by on Sprague-Dawley rats. cerebrum colchicine lesion. The behavioural assessments such as locomotor activity, spatial navigation task, open ...

Abstract Introduction The available treatments for Peyronie’s Disease as recommended by international guidelines are either surgery or intralesional injection therapy. In recently cell and rat studies it has been shown that using a phosophdiesterase type 5 inhibitor (PDE5i) selective oestrogen receptor modulator (Tamoxifen) inhibited myofibroblast transformation extracellular matrix production....

Borna disease virus (BDV) is a negative-strand RNA virus which produces persistent infection in a variety of experimental animals. In the rat, the presence or absence of clinical signs of Borna disease, a characteristic, biphasic neurobehavioral illness, depends on host-related factors. A window of opportunity exists after birth wherein inoculation with BDV produces a persistently infected rat ...

Large numbers of inbred laboratory rat strains have been developed for a range of complex disease phenotypes. To gain insights into the evolutionary pressures underlying selection for these phenotypes, we sequenced the genomes of 27 rat strains, including 11 models of hypertension, diabetes, and insulin resistance, along with their respective control strains. Altogether, we identified more than...

abstractparkinson’s disease (pd) is a neuropathological and debilitating disorder involving the degeneration of mesencephalic dopaminergic neurons. neuroprotective effect of hesperetin has already been reported, therefore, this study examined whether the administration of this flavonoid would attenuate behavioral abnormalities in an experimental model of pd in rat. for this purpose, unilateral ...

Francisella tularensis, a highly infectious bacterium, is the causative agent of Tularemia (rabbit fever). Categorized by Center for Disease Control and Prevention as Category A bioterrorism agent, tularensis highest level concern. Previously, we identified that dillapiole, compound extracted from fennel, dampens F. virulence gene expression. While having no apparent effect on viability treatme...

this study aimed to explore and validate a new juvenile osteopenic (jo) rat model then examine the efficacy of moghat (glossostemon bruguieri) as an alternative reversal therapy for jo. phytochemical screening analysis showed that moghat contains 5.8% alkaloids, 1.5% flavonoids and 13.2% total phenols. juvenile osteopenia was induced in 15 days old sprague- dawley female rats by feeding them fr...

The impact of the strength and promiscuity of the self peptide-MHC class II interaction on susceptibility to autoimmune disease is uncertain. Here we studied allelic differences in the affinity of rat MHC class II molecules for myelin basic protein (MBP) peptides spanning from position 63 to 106. Predominantly peptides from this region are immunogenic in the rat and the MHC class II region dete...