Among all inborn errors of metabolism lysosomal storage diseases occupy an important place, because they have a diverse clinical symptoms, manifest at different ages and are disguised as diseases, which makes the diagnosis these quite difficult long-term. Niemann-Pick disease, rare inherited neurodegenerative disease caused by disruption intracellular lipid metabolism, is one such disease. The ...

Background and Objectives: As an autoimmune disease, celiac is triggered by exposure to dietary gluten in genetically susceptible individuals, leading to various gastrointestinal and non-gastrointestinal symptoms. The aim of the current study was to accurately investigate epidemiology of the celiac disease in Hamadan Province, Iran. Materials and Methods: This study was carried out as a case s...

visceral leishmaniasis is a protozoar disease caused by l.donovani. transmission to humans (incidental host) occurs via insect bite and the phlebotomous (female sand-fly) transmits the disease. common presentations of the disease include hepatomegaly and splenomegaly, but fever, chills and night sweats may be part of the disease's symptoms. lymphadenopathy without systemic manifestations i...

Kawasaki disease is a systemic vasculitis of children. Among gastrointestinal symptoms of this disease jaundice occurs uncommonly. We present a 23 month boy with icter and clinical hepatitis and final diagnosis of kawasaki disease.

carcinoid tumor is a slow-growing type of neuroendocrine tumor, originating in the enterochromaffin cells and secreting mainly serotonin. the diagnosis is based on clinical symptoms, hormone levels, radiological and nuclear imaging, and histological confirmation. the clinical symptoms are characterized by flushing, diarrhea, abdominal pain, telangiectasia and/or bronchoconstriction. however, mo...

Neuropsychiatric symptoms are common in Parkinson's disease, even at the earliest stages, and have important consequences for quality of life and daily functioning, are associated with increased carer burden and increased risk for nursing home admission. In addition to cognitive impairment, a wide range of neuropsychiatric symptoms have been reported. In this article, the epidemiology, clinical...

objective wilson disease (wd) is an inherited copper metabolism dysfunction disease characterized by cirrhosis and cns findings. wilson disease is important because it is fatal if not recognized and treated. our goal of study is to investigate the clinical signs and symptoms, lab results and other relevant matters in our patients in order to obtain a better understanding of this potentially let...

Depression occurs in approximately 45% of all patients with Parkinson's disease (PD), does not correlate with the stage of motor deficits, reduces quality of life independently of motor symptoms and appears to be underrated and undertreated. Anxiety and depression are the risk factors for the development of PD and may be present many years before the appearance of motor symptoms. Studies using ...

IMPORTANCE: Since the outbreak of coronavirus disease 2019 (COVID-19), various digestive symptoms have been frequently reported in a significant portion of patients infected with the virus. It is well established that most patients with COVID-19 have fever along with respiratory signs and symptoms, such as cough and dyspnea. We present 36 cases with chief complaint of gastrointestinal (GI) symp...