Designing the physical distribution network in a supply chain is an important strategic planning problem with undeniable implications towards tactical and operational planning success. In this paper we consider a distribution network made up of four tiers, involving factories, central warehouses, regional warehouses as well as customer zones. The objective is to select the optimal numbers and l...

Introduction: The complex geometry of breast and also lung and heart inhomogeneities near the planning target volume (PTV) result in perturbations in dose distribution. This problem can result in overdosage or underdosage in the match region of the three treatment fields. The purpose of this study is to create a homogeneous dose distribution in the match region between the supraclavicular and t...

We consider tactical planning for a particular class of multi-period vehicle routing problems (MPVRP). This problem involves optimizing product collection and distribution from several production locations to a set of processing plants over a planning horizon. Each horizon consists of several days, and the collection-distribution are performed on a repeating daily basis. In this context, a sing...

In this paper we consider the problem of planning the production and distribution in a supply chain. The situation consists in a set of distribution centers seeking to serve to a set of retailers; these distribution centers are supplied by a set of plants trying to minimize the operation and transportation costs. The problem is formulated as a bilevel mathematical problem where the upper level ...

In this paper we study the Multi-period Vehicle Routing Problem with Due dates (MVRPD), where customers have to be served between a release and a due date. Customers with due dates exceeding the planning period may be postponed at a cost. A fleet of capacitated vehicles is available to perform the distribution in each day of the planning period. The objective of the problem is to find vehicle r...

T integrated production and distribution problem with bidirectional flows is a complicated optimization problem, usually with large problem sizes when encountered in practice. In this study, we propose a partial linear programming relaxation-based heuristic approach to solve a variation of this problem. The approach is called a partial relaxation in the sense that it relaxes the integer require...

This paper describes a Bayesian method for optimum accelerated life test planning with one accelerating variable, when the acceleration model is linear in the parameters, based on censored data from a log-location-scale distribution. We use a Bayesian criterion based on estimation precision of a distribution quantile at a specified use condition and use this criterion to find optimum test plans...

Today, many companies after achieving improvements in manufacturing operations are focused on the improvement of distribution systems and have long been a strong tendency to optimize the distribution network in order to reduce logistics costs that the debate has become challenging. Improve the flow of materials, an activity considered essential to increase customer satisfaction. In this study, ...

the territory of serbia is vulnerable to various types of natural hazards and the risk is not equal across the entire territory; it varies depending on the type of hazard and the expected potential for damage. the first aim of this research was to determine the geographical distributions of the major types of natural hazards. seismic hazards, landslides, rock falls, floods, torrential floods...